Murhekar M V, Kulkarni H R, Zodpey S P, Dehankar A G
Department of Preventive and Social Medicine, Government Medical College, Nagpur, India.
Tuber Lung Dis. 1995 Dec;76(6):545-9. doi: 10.1016/0962-8479(95)90532-4.
Government Medical College, Nagpur, India, a tertiary care hospital.
To estimate the effectiveness of mass neonatal BCG vaccination in the prevention of pulmonary tuberculosis in Nagpur, India.
A hospital-based pair-matched case-control study with a case of 1:3, including 144 cases of pulmonary tuberculosis and 432 controls.
The overall vaccine effectiveness estimated in the present study was 60% (95% Confidence Interval [CI] 43%-72%). The protective effect was more in males in the age group 21-30 years. The prevented fraction was 39% (95% CI 24%-52%).
The moderate effectiveness demonstrated in this study needs to be substantiated for other forms of tuberculosis by undertaking community-based case-control studies, before attempting to justify the use of mass neonatal BCG vaccination strategy as a part of the national programme.
印度那格浦尔的政府医学院，一家三级医疗机构。
评估印度那格浦尔大规模新生儿卡介苗接种在预防肺结核方面的效果。
一项基于医院的配对病例对照研究，病例与对照比例为1:3，包括144例肺结核病例和432例对照。
本研究估算的总体疫苗效力为60%（95%置信区间[CI] 43%-72%）。在21至30岁年龄组中，男性的保护效果更明显。预防率为39%（95% CI 24%-52%）。
在试图将大规模新生儿卡介苗接种策略作为国家计划的一部分进行论证之前，需要通过开展基于社区的病例对照研究，来证实本研究中所显示的中等效力对其他形式肺结核的作用。
