Zodpey S P, Maldhure B R, Dehankar A G, Shrikhande S N
Dept. of Preventive and Social Medicine, Govt. Medical College, Nagpur.
J Commun Dis. 1996 Jun;28(2):77-84.
A hospital-based pair-matched case-control study was carried out at Govt. Medical College Hospital, Nagpur, to estimate the effectiveness of BCG vaccination against extra-pulmonary tuberculosis. The study included 125 cases of extra-pulmonary tuberculosis in the age group of 0-30 years and 375 tuberculosis free control. Each case was pair matched against three separate controls for age, sex and socioeconomic status. The protective effectiveness and prevented fraction were higher for the subjects in the age group of 0-10 years, males and subjects from middle and upper strata of socio-economic class but it was statistically nonsignificant. The overall vaccine effectiveness and prevented fraction was estimated to be 80.86 (72.68-86.60) and 53.20 (41.97-63.73) per cent respectively. Results of this study thus indicated that BCG vaccination was highly effective against extra-pulmonary tuberculosis and played a significant role in its prevention in this population.
在那格浦尔政府医学院医院开展了一项基于医院的配对病例对照研究，以评估卡介苗接种预防肺外结核病的效果。该研究纳入了125例0至30岁的肺外结核病例以及375名未患结核病的对照者。每例病例按照年龄、性别和社会经济地位与三名不同的对照者进行配对。0至10岁年龄组的受试者、男性以及社会经济阶层中上层的受试者的保护效力和预防率更高，但在统计学上无显著差异。总体疫苗效力和预防率估计分别为80.86（72.68 - 86.60）%和53.20（41.97 - 63.73）%。因此，本研究结果表明，卡介苗接种对肺外结核病高度有效，并在该人群的预防中发挥了重要作用。
