Tominaga M, Kimura M, Sugiyama K, Abe T, Igarashi K, Igarashi M, Eguchi H, Sekikawa A, Ogawa A, Manaka H
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Diabetes Res Clin Pract. 1995 Jul;29(1):11-7. doi: 10.1016/0168-8227(95)01116-u.
Although there is no concept of insulin resistance in traditional Kampo (Chinese) medicine and Indian medicine, we had the hypothesis that some drug in a mixture of crude drugs which was believed to ameliorate diabetes mellitus may have had the effect of improving insulin resistance. To test this hypothesis, the effects of Seishin-renshi-in (Chinese medicine) and Gymnema sylvestre (Indian medicine) on the insulin resistance of streptozotocin-induced diabetic rats was studied by the glucose clamp technique. Oral administration of Seishin-renshi-in (800 mg/kg/day) with injections of a minimum dose of Ultralente insulin decreased urine volume and urinary glucose excretion during a 7-day treatment period and improved the insulin stimulated glucose uptake in peripheral tissues, as well as improving the insulin suppressed hepatic glucose output during glucose clamp. However, G. sylvestre (120 mg/kg/day) treatment did not improve insulin resistance. We conclude that Seishin-renshi-in, with a small dose of insulin, improved insulin resistance in streptozotocin-induced diabetic rats, but Gymnema sylvestre did not.
虽然传统汉方（中医）和印度医学中没有胰岛素抵抗的概念，但我们有这样一个假设，即一些被认为可改善糖尿病的中药复方中的某些药物可能具有改善胰岛素抵抗的作用。为了验证这一假设，我们采用葡萄糖钳夹技术研究了参苓白术散（中药）和匙羹藤（印度医学用药）对链脲佐菌素诱导的糖尿病大鼠胰岛素抵抗的影响。在为期7天的治疗期间，口服参苓白术散（800毫克/千克/天）并注射最小剂量的超长效胰岛素，可减少尿量和尿糖排泄，改善外周组织中胰岛素刺激的葡萄糖摄取，并在葡萄糖钳夹期间改善胰岛素抑制的肝葡萄糖输出。然而，匙羹藤（120毫克/千克/天）治疗并未改善胰岛素抵抗。我们得出结论，参苓白术散与小剂量胰岛素联合使用可改善链脲佐菌素诱导的糖尿病大鼠的胰岛素抵抗，但匙羹藤则无此作用。
