水提取物对链脲佐菌素诱导的糖尿病小鼠具有抗糖尿病作用。

aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice.

作者信息

Eddouks Mohamed, Lemhadri Ahmed, Hebi Morad, El Hidani Ahmed, Zeggwagh Naoufel Ali, El Bouhali Bachir, Hajji Lhoussaine, Burcelin Remy

机构信息

Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.

Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco; ISPITS Rabat, Avenue Hassan II Km 4,5 Route de Casa, Rabat Maroc.

出版信息

Avicenna J Phytomed. 2017 Mar-Apr;7(2):191-198.

DOI:

PMID:28348974

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5355824/

Abstract

OBJECTIVE

As the aqueous extract of (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice.

MATERIALS AND METHODS

Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.

RESULTS

Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-H glucose demonstrated the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p<0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues.

CONCLUSION

We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice.

摘要