Barnhill R L, Bolognia J L
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
J Cutan Pathol. 1995 Oct;22(5):450-9. doi: 10.1111/j.1600-0560.1995.tb00762.x.
Neurotropic melanoma has generally been described in the context of desmoplastic melanoma. The vast majority of melanomas displaying neurotropism contain relatively little or no melanin. Herein, we report an unusual case of neurotropic melanoma with prominent melanin content. The patient developed a tumor notable for pagetoid (superficial spreading) melanoma with partial regression and a deep component characterized by perineurial aggregates of melanophages and intraneural infiltration by melanoma cells. This case serves to alert dermatopathologists to the fact that the spectrum of neurotropic melanoma includes tumors with perineurial aggregates of pigment-containing cells.
嗜神经性黑色素瘤通常是在促结缔组织增生性黑色素瘤的背景下被描述的。绝大多数表现出嗜神经性的黑色素瘤含有的黑色素相对较少或不含黑色素。在此，我们报告一例罕见的嗜神经性黑色素瘤病例，其黑色素含量显著。该患者发生了一例以派杰样（浅表扩散性）黑色素瘤伴部分消退为特征的肿瘤，深部成分表现为噬黑素细胞的神经周聚集以及黑色素瘤细胞的神经内浸润。该病例提醒皮肤病理学家注意，嗜神经性黑色素瘤的谱系包括含有色素细胞神经周聚集的肿瘤。
