Rudi A, Goldberg I, Stein Z, Kashman Y, Benayahu Y, Schleyer M, Garcia Gravalos M D
School of Chemistry, Tel-Aviv University, Israel.
J Nat Prod. 1995 Nov;58(11):1702-12. doi: 10.1021/np50125a009.
Three cytotoxic triterpenes, sodwanones G [5], H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by interpretation of nmr spectra, and in the case of 5, also on the basis of the X-ray diffraction analysis. The X-ray diffraction analysis of two other earlier reported sodwanones, E [3] and F [4] is also discussed. The cytotoxic activity against several cancer cell lines, has been tested. IC50 values between 20 and 0.02 microM were obtained. Compounds 5 and 6 were 10- and 500-fold, respectively, more cytotoxic to A-549 cells than to any of the other cell lines tested (HT-29, MEL-28, P-388).
从一种海洋海绵中分离出了三种细胞毒性三萜类化合物，即索德瓦酮G[5]、H[6]和I[7]。这三种化合物的结构通过核磁共振光谱解析确定，对于化合物5，还基于X射线衍射分析确定。还讨论了另外两种先前报道的索德瓦酮E[3]和F[4]的X射线衍射分析。测试了它们对几种癌细胞系的细胞毒性活性。获得的IC50值在20至0.02微摩尔之间。化合物5和6对A-549细胞的细胞毒性分别比测试的其他任何细胞系（HT-29、MEL-28、P-388）高10倍和500倍。
