人类肿瘤和细胞系中p53基因的体细胞点突变：最新汇编。
Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation.
作者信息
Hollstein M, Shomer B, Greenblatt M, Soussi T, Hovig E, Montesano R, Harris C C
机构信息
German Cancer Research Center, Heidelberg, Germany.
出版信息
Nucleic Acids Res. 1996 Jan 1;24(1):141-6. doi: 10.1093/nar/24.1.141.
Abstract
In 1994 we described a list of approximately 2500 point mutations in the p53 gene of human tumors and cell lines which we had compiled from the published literature and made available electronically through the file server at the EMBL Data Library. This database, updated twice a year, now contains records on 4496 published mutations (July 1995 release) and can be obtained from the EMBL Outstation-the European Bioinformatics Institute (EBI) through the network or on CD-ROM. This report describes the criteria for inclusion of data in this database, a description of the current format and a brief discussion of the current relevance of p53 mutation analysis to clinical and biological questions.
摘要
1994年，我们描述了一份从已发表文献中汇编的人类肿瘤和细胞系p53基因中约2500个点突变的列表，并通过EMBL数据库的文件服务器以电子方式提供。该数据库每年更新两次，目前包含4496个已发表突变的记录（1995年7月发布），可通过网络或光盘从EMBL分站——欧洲生物信息学研究所（EBI）获取。本报告描述了该数据库数据收录标准、当前格式说明以及对p53突变分析与临床和生物学问题当前相关性的简要讨论。
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