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通过蛋白质印迹法检测四种表征婴儿利什曼原虫所致急性临床利什曼病的抗原。

Detection by Western blot of four antigens characterizing acute clinical leishmaniasis due to Leishmania infantum.

作者信息

Marty P, Lelièvre A, Quaranta J F, Suffia I, Eulalio M, Gari-Toussaint M, Le Fichoux Y, Kubar J

机构信息

Groupe de Recherche en Immunopathologie de la Leishmaniose, Faculté de Médecine, Université de Nice-Sophia Antipolis, France.

出版信息

Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):690-1. doi: 10.1016/0035-9203(95)90447-6.

DOI:10.1016/0035-9203(95)90447-6
PMID:8594698
Abstract

Western blot analysis of sera from 32 patients with acute clinical leishmaniasis due to Leishmania infantum showed the simultaneous presence of antibodies against 4 antigens with molecular masses of 18, 21, 23, 31 kDa. The simultaneous presence of these 4 antigens was specific to the clinical disease and it was not detected in 47 sera from asymptomatic individuals living in the leishmaniasis endemic area of Alpes-Maritimes (southern France) or in 37 sera from patients with other protozoan infections.

摘要

对32例因婴儿利什曼原虫引起的急性临床利什曼病患者的血清进行蛋白质印迹分析,结果显示同时存在针对分子量分别为18、21、23、31 kDa的4种抗原的抗体。这4种抗原同时存在是该临床疾病所特有的,在居住于法国南部滨海阿尔卑斯省利什曼病流行区的47例无症状个体的血清中或37例其他原生动物感染患者的血清中均未检测到。

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