对delta9-四氢大麻酚对穿梭箱行为表现和体温影响的耐受性。

Tolerance to the effects of delta9-THC on shuttle-box performance and body temperature.

作者信息

ten Ham M

出版信息

Pharmacol Biochem Behav. 1977 Feb;6(2):183-5. doi: 10.1016/0091-3057(77)90071-5.

Abstract

Two groups of rats were trained in a shuttle-box and received delta9-tetrahydrocannabinol (delta9-THC), either before or after being tested. The drug-before group showed tolerance--within 3-6 sessions--to the response-inhibiting effect of THC. The drug-after animals appeared also to be tolerant when they received delta9-THC before being tested. It is concluded that the tolerance to this effect probably is not learned, but has a physiological base. This is corroborated by the finding that during the same study all the animals developed tolerance to the hypothermic effect of delta9-THC.

摘要

两组大鼠在穿梭箱中接受训练，并在测试前或测试后给予Δ⁹-四氢大麻酚（Δ⁹-THC）。药物先给组在3至6次训练过程中对THC的反应抑制作用产生了耐受性。药物后给组的动物在测试前接受Δ⁹-THC时似乎也产生了耐受性。得出的结论是，对这种作用的耐受性可能不是习得的，而是有生理基础的。在同一研究中所有动物对Δ⁹-THC的体温过低作用都产生了耐受性这一发现证实了这一点。