Sievers E L, Berger M, Geyer J R
Division of Pediatric Oncology, Fred Hutchison Cancer Research-Center, Seattle, Washington, USA.
Med Pediatr Oncol. 1996 Apr;26(4):293-5. doi: 10.1002/(SICI)1096-911X(199604)26:4<293::AID-MPO14>3.0.CO;2-G.
Extracranial metastasis is an unusual complication of most types of primary intracranial tumor. Approximately one-third of reported cases of primary intracranial choriocarcinoma have been associated with pulmonary tumor metastasis. The prognosis of such patients has been uniformly fatal. This report describes a probable long-term survivor of primary intracranial choriocarcinoma wit pulmonary metastasis. The patient had a complete response to combination chemotherapy with cisplatin, etoposide, and bleomycin and is surviving free of disease >3 years from diagnosis.
颅外转移是大多数原发性颅内肿瘤不常见的并发症。在报告的原发性颅内绒毛膜癌病例中,约三分之一与肺部肿瘤转移有关。这类患者的预后一直都是致命的。本报告描述了一名原发性颅内绒毛膜癌伴肺转移可能的长期存活者。该患者对顺铂、依托泊苷和博来霉素联合化疗有完全反应,自诊断后已无病存活超过3年。