Gault M H, Harding C E
Memorial University, St John's, Newfoundland, Canada.
Clin Biochem. 1996 Apr;29(2):117-24. doi: 10.1016/0009-9120(96)02028-0.
To evaluate a hand held portable i-STAT analyzer used for point-of-care testing in a hemodialysis unit.
Imprecision and comparison studies. Assays by nonlaboratory personnel.
Study of both quality control solutions and hemodialysis patients' duplicate blood specimens with 6+, E3+, EC6+, and EC8+ cartridges both gave CVs for sodium, potassium, chloride, pH, and ionized calcium of 0 to 2.2%. CVs for hematocrit, glucose and pCO2 for whole blood duplicates were 4.6, 3.5, and 4.0%. The mean differences between i-STAT and central laboratory values for the above compounds and urea, when expressed as a % of mean central laboratory values were 0.2 and 3.1%, except for an ionized calcium value of 4.3% (for which there is an explanation) and for glucose (11%) that were both higher for i-STAT. Preliminary data suggest that sodium, potassium, ionized calcium, and pH can be assayed in the aqueous dialysate fluid used for hemodialysis.
We confirm previous reports that i-STAT cartridges give simple, rapid, and reliable values for sodium, potassium, chloride, urea, glucose, and hematocrit that are clinically acceptable when performed by nonlaboratorians, but also suggest the same conclusions apply to ionized calcium, pH, and pCO2. The hemodialysis unit may prove to be one of several hospital units where the analyzer has considerable value.
评估一种用于血液透析单元即时检测的手持式便携式i-STAT分析仪。
进行不精密度和比较研究。由非实验室人员进行检测。
使用6+、E3+、EC6+和EC8+检测卡对质量控制溶液和血液透析患者的重复血液标本进行研究，钠、钾、氯、pH和离子钙的变异系数（CV）为0%至2.2%。全血重复检测的血细胞比容、葡萄糖和二氧化碳分压（pCO2）的CV分别为4.6%、3.5%和4.0%。i-STAT与中心实验室上述化合物及尿素值之间的平均差异，以中心实验室平均值的百分比表示为0.2%和3.1%，但离子钙值为4.3%（对此有解释），葡萄糖值为11%，i-STAT的这两个值均较高。初步数据表明，可对用于血液透析的水性透析液中的钠、钾、离子钙和pH进行检测。
我们证实了之前的报道，即i-STAT检测卡可为钠、钾、氯、尿素、葡萄糖和血细胞比容提供简单、快速且可靠的值，由非实验室人员操作时在临床上是可接受的，同时也表明相同结论适用于离子钙、pH和pCO2。血液透析单元可能是该分析仪具有重要价值的几个医院科室之一。
