Erickson K A, Wilding P
Department of Pathology, Hospital of University of Pennsylvania, Philadelphia 19104.
Clin Chem. 1993 Feb;39(2):283-7.
We evaluated a novel system designed for rapid, point-of-care measurement of sodium, potassium, chloride, urea nitrogen, glucose, and hematocrit. The i-STAT Portable Clinical Analyzer (PCA) system is composed of a hand-held analyzer and disposable cartridges. Sample analysis takes place in the cartridge, which contains a series of thin-film electrodes microfabricated on silicon chips. The PCA was evaluated for precision, accuracy, and utility in emergency department and stat laboratory settings. Precision did not differ significantly between these two locations, the CVs being as follows: sodium, 0.46-0.89%; potassium, 1.06-1.45%; chloride, 0.69-2.76%; urea nitrogen, 2.54-6.12%; and glucose, 4.39-5.19%. The assessment of accuracy was based on comparison of patients' sample values analyzed by the PCA and the Kodak Ektachem 700 (or the Coulter ST for hematocrit). Regression statistics were acceptable for all analytes except chloride, for which the regression data were influenced by the limited range of results. A difference plot of the chloride comparison showed that the bias rarely exceeded 5 mmol/L. Mean hematocrit values significantly differed between the PCA and the Coulter ST, apparently because of different calibration procedures.
我们评估了一种新型系统，该系统旨在对钠、钾、氯、尿素氮、葡萄糖和血细胞比容进行快速的即时检测。i-STAT便携式临床分析仪（PCA）系统由一台手持式分析仪和一次性检测卡组成。样本分析在检测卡中进行，检测卡包含一系列微制造在硅芯片上的薄膜电极。对PCA在急诊科和急诊实验室环境中的精密度、准确性和实用性进行了评估。这两个地点之间的精密度没有显著差异，变异系数如下：钠，0.46 - 0.89%；钾，1.06 - 1.45%；氯，0.69 - 2.76%；尿素氮，2.54 - 6.12%；葡萄糖，4.39 - 5.19%。准确性评估基于PCA分析的患者样本值与柯达Ektachem 700（或血细胞比容用的库尔特ST）分析结果的比较。除氯以外，所有分析物的回归统计均可接受，氯的回归数据受结果范围有限的影响。氯比较的差异图显示偏差很少超过5 mmol/L。PCA和库尔特ST之间的平均血细胞比容值有显著差异，显然是由于校准程序不同。
