Shoenut J P, Yamashiro Y, Orr W C, Kerr P, Micflikier A B, Kryger M H
Department of Medicine, University of Manitoba, Winnipeg, Canada.
Dig Dis Sci. 1996 Feb;41(2):372-6. doi: 10.1007/BF02093831.
Polysomnography and esophageal pH studies were conducted in 13 patients with an aperistaltic esophagus; seven of these had scleroderma and six were patients treated for achalasia. The percentage total time of pH<4.0 when recumbent exceeded 30% for both groups. There was a total of 51 reflux events for both groups. There were 22 reflux events recorded for both groups that were less than 5 min in length and 29 events greater than 5 min. In 26 of 32 (81%) instances, patients either began awake and went to sleep during a reflux event or did not awake during a reflux event. Only six of 32 (19%) reflux events caused sleep disruption. We conclude that even the severe reflux demonstrated in this subset of patients does not always disrupt sleep. Patients may have severe prolonged reflux and not arouse.
对13例食管蠕动消失的患者进行了多导睡眠图和食管pH值研究；其中7例患有硬皮病，6例为接受贲门失弛缓症治疗的患者。两组患者仰卧位时pH值<4.0的总时间百分比均超过30%。两组共有51次反流事件。两组记录到的反流事件中，有22次持续时间小于5分钟，29次持续时间大于5分钟。在32例（81%）的情况中，患者要么在反流事件开始时清醒然后入睡，要么在反流事件期间未醒来。32次反流事件中只有6次（19%）导致睡眠中断。我们得出结论，即使在这部分患者中表现出的严重反流也并不总是会干扰睡眠。患者可能有严重的长时间反流但未觉醒。
