Yumita N, Umemura S, Kaneuchi M, Okano Y, Magario N, Ishizaki M, Shimizu K, Sano Y, Umemura K, Nishigaki R
School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.
Cancer Lett. 1998 Mar 13;125(1-2):209-14. doi: 10.1016/s0304-3835(97)00515-6.
The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 microM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.
研究了含氟蒽环类衍生物（FAD104）的超声诱导体外细胞损伤作用。将悬浮于空气饱和磷酸盐缓冲盐溶液（PBS）中的肉瘤180细胞在有和没有FAD104存在的情况下暴露于超声长达60秒。在80微摩尔FAD104存在时，超声诱导细胞损伤的速率加倍，而单独使用FAD104时未观察到细胞损伤。组氨酸可显著抑制这种增强作用，这可能提示了一种声化学机制。
