小鼠XPC cDNA序列与人XPC基因的基因组结构
Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene.
作者信息
Li L, Peterson C, Legerski R
机构信息
Department of Molecular Genetics, University of Texas, M.D. Anderson Cancer Center, Houston USA.
出版信息
Nucleic Acids Res. 1996 Mar 15;24(6):1026-8. doi: 10.1093/nar/24.6.1026.
Abstract
The full length-mouse XPC cDNA contains a 2703 bp orf which encodes a polypeptide containing 900 amino acids. Overall, there is 75% identity in nucleotide sequence and 73% identity in amino acid sequence between mouse and human genes. The C-terminal half is more conserved (80%) than the N-terminal half (65%). Northern analysis has revealed a constitutive expression pattern for both human and mouse transcripts in various tissues examined. However, high level expression was observed in liver, testis and kidney in both species. The human XPC gene was cloned from a cosmid library and the full-length gene was found to span -24 kb. Analysis of the genomic structure indicated that the transcribed sequence is divided into 15 exons.
摘要
全长小鼠XPC cDNA含有一个2703 bp的开放阅读框，其编码一个包含900个氨基酸的多肽。总体而言，小鼠和人类基因之间的核苷酸序列同一性为75%，氨基酸序列同一性为73%。C端的一半比N端的一半更保守（80%对65%）。Northern分析显示，在检测的各种组织中，人类和小鼠转录本均呈现组成型表达模式。然而，在这两个物种的肝脏、睾丸和肾脏中均观察到高水平表达。人类XPC基因是从一个粘粒文库中克隆出来的，发现全长基因跨度为-24 kb。基因组结构分析表明，转录序列被分为15个外显子。
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