乙醇摄入后循环中的总镁和离子化镁

Circulating total and ionized magnesium after ethanol ingestion.

作者信息

Wu C, Kenny M A

机构信息

Dept. of Laboratory Medicine, School of Medicine, University of Washington, Seattle, 98195, USA.

出版信息

Clin Chem. 1996 Apr;42(4):625-9.

PMID:8605682

Abstract

Hypomagnesemia is associated with alcoholism (Lim P, Jacob E. Metabolism 1972;21:1045-51). Here we assess two measurements of blood magnesium in emergency care patients with confirmed ethanol ingestion. Serum total and ionized magnesium (tMg, iMg) were measured in 88 patients with ethanol concentrations of 6-128 mmol/L and in sera of 97 hospitalized patients (control group). iMg was measured by an ion-selective electrode method; tMg was measured spectrophotometrically. iMg was significantly lower for the ethanol-containing specimens (0.35 +/- 0.12 mmol/L, mean +/- SD) than for the control group (0.46 +/- 0.15 mmol/L), with P <0.0001. The tMg for the test group (0.87 +/- 0.20 mmol/L) was not significantly different from the controls (0.88 +/- 0.33 mmol/L), with P = 0.5987. tMg was not well-correlated with iMg in the ethanol-positive specimens. Most ethanol-positive patients had abnormally low serum iMg (87 of 88 had iMg <0.53 mmol/L).

摘要

低镁血症与酒精中毒有关（林P，雅各布E。《新陈代谢》1972年；21:1045 - 51）。在此，我们评估了确诊摄入乙醇的急诊患者的两种血镁测量方法。对88例乙醇浓度为6 - 128 mmol/L的患者以及97例住院患者（对照组）的血清进行了总镁和离子镁（tMg，iMg）测量。离子镁采用离子选择电极法测量；总镁采用分光光度法测量。含乙醇标本的离子镁（0.35±0.12 mmol/L，平均值±标准差）显著低于对照组（0.46±0.15 mmol/L），P<0.0001。试验组的总镁（0.87±0.20 mmol/L）与对照组（0.88±0.33 mmol/L）无显著差异，P = 0.5987。在乙醇阳性标本中，总镁与离子镁相关性不佳。大多数乙醇阳性患者血清离子镁异常低（88例中有87例离子镁<0.53 mmol/L）。