Helpap B
Institute of Pathology, General Hospital of Singen, Academic Instructional Hospital of University of Freiburg, Germany.
Pathol Res Pract. 1995 Sep;191(9):904-7. doi: 10.1016/S0344-0338(11)80975-1.
To investigate possible cell kinetic relations between benign prostatic hyperplasia (BPH), atypical adenomatous hyperplasia (AAH), prostatic intraepithelial neoplasia (PIN) and carcinoma, cell kinetic analyses were performed using radiolabelled DNA-precursors (3H-thymidine autoradiography), immunohistochemistry (proliferation marker Ki67/MIB1 and/or PCNA) and silver staining of nucleolar organizer regions (AgNOR). All methods yielded the lowest values for BPH and AAH, while maximal values were found in carcinoma of high malignancy. PIN was equal to GII-carcinomas, while AAH was between BPH and carcinoma of low malignancy. This investigation ranks BPH, AAH, low grade carcinoma, PIN and high grade carcinoma in order using different methods of cell kinetic analysis. The preneoplastic character of PIN is apparent whereas the character of AAH remains uncertain.
为研究良性前列腺增生（BPH）、非典型腺瘤样增生（AAH）、前列腺上皮内瘤变（PIN）与癌之间可能的细胞动力学关系，采用放射性标记的DNA前体（3H-胸腺嘧啶放射自显影）、免疫组织化学（增殖标志物Ki67/MIB1和/或PCNA）以及核仁组织区银染（AgNOR）进行细胞动力学分析。所有方法得出的BPH和AAH值最低，而在高恶性癌中发现最大值。PIN与GII级癌相当，而AAH介于BPH和低恶性癌之间。本研究使用不同的细胞动力学分析方法对BPH、AAH、低级别癌、PIN和高级别癌进行排序。PIN的癌前特征明显，而AAH的特征仍不确定。
