Vos P J, Folgering H T, van Herwaarden C L
Department of Pulmonary Diseases, University of Nijmegen, Medical Centre Dekkerswald, Groesbeek, The Netherlands.
Biol Psychol. 1995 Nov 16;41(3):295-305. doi: 10.1016/0301-0511(95)05140-6.
The selective visual attention of 39 patients with chronic obstructive pulmonary disease (COPD) was measured by the Bourdon-Vos test and compared with the attention performance of 38 healthy controls of the same age range. The correlation between the attention of the COPD patients and day- and night-time parameters was determined. Furthermore, in 44 other COPD patients with daytime hypoxaemia, the effect of one night of oxygen supplementation and of a 7-day treatment with two respiratory stimulants (chlormadinone acetate) (CMA) or acetazolamide (ACET) on attention performance was studied. The results showed that the attention performance of COPD patients was lower than that of controls. Significant correlations were found between the mean line time (attention parameter) and the following parameters: age, inspiratory vital capacity (IVC), hypercapnic ventilatory response (HCVR), daytime arterial oxygen saturation (SaO2), daytime arterial oxygen pressure (PaO2), daytime arterial carbon dioxide pressure (PaCO2), mean nocturnal SaO2, lowest nocturnal SaO2 and the standard deviation of the mean nocturnal SaO2. Multiple linear regression analysis showed that, apart from age, only the nadir of the nocturnal SaO2 contributed to the prediction of the attention. No clinically important short-term effect of oxygen or respiratory stimulating therapy on the attention performance was found.
采用布尔东-沃斯测试测量了39例慢性阻塞性肺疾病（COPD）患者的选择性视觉注意力，并与38名年龄范围相同的健康对照者的注意力表现进行了比较。确定了COPD患者注意力与昼夜参数之间的相关性。此外，在另外44例白天低氧血症的COPD患者中，研究了一晚吸氧以及使用两种呼吸兴奋剂（醋酸氯地孕酮）（CMA）或乙酰唑胺（ACET）进行7天治疗对注意力表现的影响。结果显示，COPD患者的注意力表现低于对照组。发现平均线时间（注意力参数）与以下参数之间存在显著相关性：年龄、吸气肺活量（IVC）、高碳酸通气反应（HCVR）、白天动脉血氧饱和度（SaO2）、白天动脉血氧分压（PaO2）、白天动脉血二氧化碳分压（PaCO2）、夜间平均SaO2、夜间最低SaO2以及夜间平均SaO2的标准差。多元线性回归分析表明，除年龄外，只有夜间SaO2的最低点有助于预测注意力。未发现吸氧或呼吸刺激疗法对注意力表现有临床上重要的短期影响。
