Enomoto Y, Shiomi K, Hayashi M, Masuma R, Kawakubo T, Tomosawa K, Iwai Y, Omura S
Reseaarch Center for Biological Function, The Kitasato Institute, Tokyo 108, Japan.
J Antibiot (Tokyo). 1996 Jan;49(1):50-3. doi: 10.7164/antibiotics.49.50.
A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC50 value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 microM, respectively.
一种新的赫曲林类似物——赫曲林B，是从赫曲青霉Fg372的培养液中分离得到的。赫曲林B含有一个哌嗪和两个环己烯酮。赫曲林A的吡咯烷环断裂生成赫曲林B。赫曲林B对ADP和血小板活化因子诱导的血小板聚集的IC50值分别为1.6和5.0微摩尔。
