赫曲林，一种由赫曲青霉产生的新生物碱。发酵、分离及性质。
Herquline, a new alkaloid produced by Penicillium herquei. Fermentation, isolation and properties.
作者信息
Omura S, Hirano A, Iwai Y, Masuma R
出版信息
J Antibiot (Tokyo). 1979 Aug;32(8):786-90. doi: 10.7164/antibiotics.32.786.
PMID:500499
Abstract
A new alkaloid named herquline has been isolated from culture broth of Penicillium herquei Fg-372 by solvent extraction and silica gel chromatography. The molecular formula of herquline has been determined as C19H26N2O2 on the basis of elemental analysis and its high resolution mass spectrometry. The compound does not possess antimicrobial activities, but weakly inhibits blood platelet aggregation induced by adenosine diphosphate.
摘要
通过溶剂萃取和硅胶柱色谱法，从赫克青霉Fg - 372的培养液中分离出一种名为赫曲林的新生物碱。基于元素分析及其高分辨率质谱，确定赫曲林的分子式为C₁₉H₂₆N₂O₂。该化合物不具有抗菌活性，但能微弱抑制二磷酸腺苷诱导的血小板聚集。
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