Takamatsu S, Kim Y P, Hayashi M, Hiraoka H, Natori M, Komiyama K, Omura S
The Kitasato Institute, Tokyo, Japan.
J Antibiot (Tokyo). 1996 Jan;49(1):95-8. doi: 10.7164/antibiotics.49.95.
New anticell-adherence compounds, macrosphelides A and B, were isolated from the fermentation broth of Microsphaeropis sp. FO-5050, and their structures were elucidated by spectroscopic methods and chemical transformations. Macrosphelides A (M.W. 342, C16H22O8) and B (M.W. 340, C16H20O8) with three esters in their molecules were classified as 16-membered macrocyclic compounds. Macrosphelide B was found to be a corresponding oxidative product of macrosphelide A at the C-14 position.
新型抗细胞黏附化合物大球霉素A和B，是从微球壳菌属菌株FO - 5050的发酵液中分离得到的，其结构通过光谱方法和化学转化得以阐明。大球霉素A（分子量342，C₁₆H₂₂O₈）和B（分子量340，C₁₆H₂₀O₈）分子中含有三个酯基，被归类为16元大环化合物。发现大球霉素B是大球霉素A在C - 14位的相应氧化产物。
