长期压力会改变老年人对流感病毒疫苗的免疫反应。
Chronic stress alters the immune response to influenza virus vaccine in older adults.
作者信息
Kiecolt-Glaser J K, Glaser R, Gravenstein S, Malarkey W B, Sheridan J
机构信息
Department of Psychiatry, The Ohio State University College of Medicine, Columbus 43210, USA.
出版信息
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3043-7. doi: 10.1073/pnas.93.7.3043.
Abstract
To determine whether a chronic stressor (caregiving for a spouse with a progressive dementia) is associated with an impaired immune response to influenza virus vaccination, we compared 32 caregivers' vaccine responses with those of 32 sex-, age-, and socioeconomically matched control subjects. Caregivers showed a poorer antibody response following vaccination relative to control subjects as assessed by two independent methods, ELISA and hemagglutination inhibition. Caregivers also had lower levels of in vitro virus-specific-induced interleukin 2 levels and interleukin 1beta; interleukin 6 did not differ between groups. These data demonstrate that down-regulation of the immune response to influenza virus vaccination is associated with a chronic stressor in the elderly. These results could have implications for vulnerability to infection among older adults.
摘要
为了确定一种慢性应激源（照顾患有进行性痴呆的配偶）是否与流感病毒疫苗接种的免疫反应受损有关，我们将32名护理人员的疫苗反应与32名性别、年龄和社会经济状况相匹配的对照受试者的反应进行了比较。通过酶联免疫吸附测定（ELISA）和血凝抑制这两种独立方法评估发现，与对照受试者相比，护理人员接种疫苗后的抗体反应较差。护理人员体外病毒特异性诱导的白细胞介素2水平和白细胞介素1β水平也较低；两组之间白细胞介素6水平没有差异。这些数据表明，老年人对流感病毒疫苗接种的免疫反应下调与慢性应激源有关。这些结果可能对老年人的感染易感性有影响。
相似文献
1
Chronic stress alters the immune response to influenza virus vaccine in older adults.长期压力会改变老年人对流感病毒疫苗的免疫反应。
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3043-7. doi: 10.1073/pnas.93.7.3043.
2
Caregiving, repetitive thought, and immune response to vaccination in older adults.老年人的照料护理、重复性思维与疫苗接种的免疫反应
Brain Behav Immun. 2008 Jul;22(5):744-52. doi: 10.1016/j.bbi.2007.11.004. Epub 2007 Dec 31.
3
Chronic psychosocial stress: does it modulate immunity to the influenza vaccine in Hong Kong Chinese elderly caregivers?慢性心理社会压力：它是否会调节香港华裔老年护理人员对流感疫苗的免疫反应？
Age (Dordr). 2013 Aug;35(4):1479-93. doi: 10.1007/s11357-012-9449-z. Epub 2012 Jul 8.
4
Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination.老年痴呆症患者照料者的慢性压力与流感疫苗接种的抗体反应
Lancet. 1999 Feb 20;353(9153):627-31. doi: 10.1016/S0140-6736(98)06098-X.
5
The influence of psychological stress on the immune response to vaccines.心理压力对疫苗免疫反应的影响。
Ann N Y Acad Sci. 1998 May 1;840:649-55. doi: 10.1111/j.1749-6632.1998.tb09603.x.
6
Chronic stress associated with spousal caregiving of patients with Alzheimer's dementia is associated with downregulation of B-lymphocyte GH mRNA.与阿尔茨海默病痴呆患者配偶照料相关的慢性应激与B淋巴细胞生长激素信使核糖核酸的下调有关。
J Gerontol A Biol Sci Med Sci. 1999 Apr;54(4):M212-5. doi: 10.1093/gerona/54.4.m212.
7
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.慢性应激与促炎细胞因子白细胞介素-6随年龄增长而增加。
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5. doi: 10.1073/pnas.1531903100. Epub 2003 Jul 2.
8
Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals.运动和心理社会因素可调节老年人对流感疫苗的免疫反应。
J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):M557-62. doi: 10.1093/gerona/57.9.m557.
9
Cellular immune responses to acute stress in female caregivers of dementia patients and matched controls.痴呆症患者女性照料者及匹配对照组对急性应激的细胞免疫反应。
Health Psychol. 1998 Mar;17(2):182-9. doi: 10.1037//0278-6133.17.2.182.
10
Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging.与慢性应激和衰老相关的Th-1向Th-2细胞因子反应转变的证据。
J Gerontol A Biol Sci Med Sci. 2001 Aug;56(8):M477-82. doi: 10.1093/gerona/56.8.m477.
引用本文的文献
1
PA and PA-X: two key proteins from segment 3 of the influenza viruses.PA和PA-X：流感病毒第3节段的两种关键蛋白。
Front Cell Infect Microbiol. 2025 Mar 14;15:1560250. doi: 10.3389/fcimb.2025.1560250. eCollection 2025.
2
Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes.神经内分泌、细胞因子和细胞过程背景下应激诱导的免疫抑制调控
Biology (Basel). 2025 Jan 15;14(1):76. doi: 10.3390/biology14010076.
3
Introduction to the special issue: A festschrift for Janice Kiecolt-Glaser - At the origin of stress and immunity.特刊引言：献给贾尼斯·基科尔特-格拉泽的纪念文集——应激与免疫的起源
Compr Psychoneuroendocrinol. 2024 Oct 31;20:100274. doi: 10.1016/j.cpnec.2024.100274. eCollection 2024 Nov.
4
A Comprehensive Review on Immunoregulatory Effects of Phytochemicals.植物化学物免疫调节作用的综合综述
Curr Drug Discov Technol. 2025;22(3):e15701638326442. doi: 10.2174/0115701638326442241118053543.
5
The post-Cartesian dilemma: Reuniting the mind and body through psychoneuroimmunology.笛卡尔之后的困境：通过心理神经免疫学实现身心重聚。
Compr Psychoneuroendocrinol. 2024 Sep 26;20:100265. doi: 10.1016/j.cpnec.2024.100265. eCollection 2024 Nov.
6
Chronic stimulation desensitizes β2-adrenergic receptor responses in natural killer cells.慢性刺激会使自然杀伤细胞中的β2 - 肾上腺素能受体反应脱敏。
Eur J Immunol. 2024 Dec;54(12):e2451299. doi: 10.1002/eji.202451299. Epub 2024 Sep 30.
7
Psychoneuroimmunology and the research of Janice Kiecolt-Glaser: It informs self-care and the practice of medicine.心理神经免疫学与贾尼斯·基科尔特-格拉泽的研究：它为自我护理和医学实践提供了依据。
Compr Psychoneuroendocrinol. 2024 Aug 22;20:100260. doi: 10.1016/j.cpnec.2024.100260. eCollection 2024 Nov.
8
Caring about the family caregiver: A mentored journey building on the legacy of Janice Kiecolt-Glaser's pioneering research on caregivers' immune health.关爱家庭照顾者：一段基于贾尼斯·基科尔特-格拉泽对照顾者免疫健康的开创性研究遗产的指导之旅。
Compr Psychoneuroendocrinol. 2024 Aug 5;20:100259. doi: 10.1016/j.cpnec.2024.100259. eCollection 2024 Nov.
9
Turning stress into success: A festschrift in honor of Janice Kiecolt-Glaser.将压力转化为成功：献给贾尼斯·基科尔特-格拉泽的纪念文集。
Compr Psychoneuroendocrinol. 2024 Jul 23;19:100251. doi: 10.1016/j.cpnec.2024.100251. eCollection 2024 Aug.
10
Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Following Prior Infection or Vaccination.感染或接种疫苗后感染严重急性呼吸综合征冠状病毒 2 的风险。
J Infect Dis. 2024 Sep 23;230(3):e584-e590. doi: 10.1093/infdis/jiae130.
本文引用的文献
1
Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine.感知到的心理压力和痛苦对低剂量重组DNA乙肝疫苗抗体反应的影响。
J Psychosom Res. 1993 May;37(4):361-9. doi: 10.1016/0022-3999(93)90138-6.
2
Impact of influenza on mortality in relation to age and underlying disease, 1967-1989.1967年至1989年期间流感对与年龄和基础疾病相关的死亡率的影响
Int J Epidemiol. 1993 Apr;22(2):334-40. doi: 10.1093/ije/22.2.334.
3
Depression and immunity: a meta-analytic review.抑郁症与免疫力：一项荟萃分析综述
Psychol Bull. 1993 May;113(3):472-86. doi: 10.1037/0033-2909.113.3.472.
4
Cytokine mediators of immunity and inflammation.免疫与炎症的细胞因子介质
Arch Surg. 1993 Nov;128(11):1235-41. doi: 10.1001/archsurg.1993.01420230063010.
5
Efficacy of an influenza hemagglutinin-diphtheria toxoid conjugate vaccine in elderly nursing home subjects during an influenza outbreak.流感血凝素 - 白喉类毒素结合疫苗在流感暴发期间对老年疗养院受试者的疗效。
J Am Geriatr Soc. 1994 Mar;42(3):245-51. doi: 10.1111/j.1532-5415.1994.tb01746.x.
6
Subtype specific ELISA for the detection of antibodies against influenza A H1N1 and H3N2 in swine.用于检测猪体内抗甲型H1N1和H3N2流感病毒抗体的亚型特异性酶联免疫吸附测定
J Virol Methods. 1993 Dec 15;45(2):121-36. doi: 10.1016/0166-0934(93)90097-b.
7
8
9
Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults.慢性应激、社会支持与老年人自然杀伤细胞对细胞因子反应的持续改变。
Health Psychol. 1994 Jul;13(4):291-8. doi: 10.1037//0278-6133.13.4.291.
10
Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction.糖皮质激素与免疫功能：激素功能紊乱的生理相关性及致病潜力
Trends Pharmacol Sci. 1995 Jun;16(6):193-7. doi: 10.1016/s0165-6147(00)89021-5.
Zotero 插件