地高辛治疗监测：II. 表观分布容积的决定因素。
Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.
作者信息
Aronson J K, Grahame-Smith D G
出版信息
Br J Clin Pharmacol. 1977 Apr;4(2):223-7. doi: 10.1111/j.1365-2125.1977.tb00698.x.
Abstract
1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of the Vd of digoxin. 5 Digoxin requirements may be predictable before therapy commences if IC50 measurements are performed.
摘要
- 在18名接受地高辛治疗的受试者中，已计算出该药物的表观分布容积（Vd）。2. 对每个受试者，已测量其治疗前红细胞的86Rb转运机制对体外地高辛抑制的敏感性（IC50）。3. 地高辛的Vd与患者年龄以及他们治疗前红细胞的IC50均相关。4. 根据地高辛Vd的可能决定因素讨论了这些发现的意义。5. 如果进行IC50测量，地高辛需求量在治疗开始前可能是可预测的。
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本文引用的文献
1
ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.钠离子和钾离子跨细胞膜主动运输的酶学基础
Physiol Rev. 1965 Jul;45:596-617. doi: 10.1152/physrev.1965.45.3.596.
2
Blood levels of drug at the equilibrium state after multiple dosing.多次给药后达到平衡状态时药物的血药浓度。
Nature. 1965 Sep 18;207(5003):1301-2. doi: 10.1038/2071301a0.
3
Digoxin metabolism in the elderly.老年人地高辛的代谢
Circulation. 1969 Apr;39(4):449-53. doi: 10.1161/01.cir.39.4.449.
4
Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.采用放射免疫分析法测定治疗性和中毒性血清地高辛浓度。
N Engl J Med. 1969 Nov 27;281(22):1212-6. doi: 10.1056/NEJM196911272812203.
5
Effects of digoxin-specific antibodies on accumulation and binding of digoxin by human erythrocytes.地高辛特异性抗体对人红细胞摄取和结合地高辛的影响。
J Clin Invest. 1973 Aug;52(8):1820-33. doi: 10.1172/JCI107364.
6
The bioavailability of other digoxin preparations compared with tablets.与片剂相比，其他地高辛制剂的生物利用度。
Postgrad Med J. 1974 Nov;50 Suppl 6:62-6.
7
The biological availability of very rapidly dissolving digoxin tablets.速溶地高辛片的生物利用度。
Postgrad Med J. 1974 Nov;50 Suppl 6:55-9.
8
Effect of age and cardiac glycosides on the activity of adenosine triphosphatase (ATPase) (EC 3.6.1.3) of red cell ghost membranes.年龄和强心苷对红细胞血影膜三磷酸腺苷酶（ATP酶）（EC 3.6.1.3）活性的影响。
Mech Ageing Dev. 1974 Nov-Dec;3(5-6):245-52. doi: 10.1016/0047-6374(74)90021-9.
9
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10
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Trans Assoc Am Physicians. 1968;81:213-20.
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