监测地高辛治疗：I. 血浆浓度及组织反应的体外测定
Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response.
作者信息
Aronson J K, Grahame-Smith D G, Hallis K F, Hibble A, Wigley F
出版信息
Br J Clin Pharmacol. 1977 Apr;4(2):213-21. doi: 10.1111/j.1365-2125.1977.tb00697.x.
Abstract
1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake by the patients' own red cells fell from pre-treatment values during digitalization. 4 The therapeutic response of patients with atrial fibrillation correlated better with the changes in 86Rb uptake than with plasma digoxin concentrations.
摘要
本文描述了一种用于测量人红细胞摄取⁸⁶Rb的体外技术。
15名患者因心房颤动和其他快速心律失常接受地高辛治疗。
在洋地黄化期间，患者自身红细胞对⁸⁶Rb的摄取量低于治疗前值。
心房颤动患者的治疗反应与⁸⁶Rb摄取量的变化相关性比与血浆地高辛浓度的相关性更好。
相似文献
1
Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response.监测地高辛治疗：I. 血浆浓度及组织反应的体外测定
Br J Clin Pharmacol. 1977 Apr;4(2):213-21. doi: 10.1111/j.1365-2125.1977.tb00697.x.
2
Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.地高辛治疗监测：II. 表观分布容积的决定因素。
Br J Clin Pharmacol. 1977 Apr;4(2):223-7. doi: 10.1111/j.1365-2125.1977.tb00698.x.
3
Quinidine-digoxin interaction: effect of quinidine on 86Rb-uptake of human erythrocytes.奎尼丁-地高辛相互作用：奎尼丁对人红细胞摄取⁸⁶Rb的影响
Klin Wochenschr. 1981 Jan 15;59(2):95-6. doi: 10.1007/BF01477289.
4
Factors influencing the inhibition by digoxin of 86 Rubidium uptake into human red cells.影响地高辛对铷86摄入人红细胞抑制作用的因素。
Med Lab Sci. 1979;36(4):339-52.
5
The influence of metabolites of digoxin and digitoxin on the 86Rb-uptake assay.地高辛和洋地黄毒苷的代谢产物对86Rb摄取试验的影响。
Eur J Clin Pharmacol. 1973 Jun;6(1):54-6. doi: 10.1007/BF00561801.
6
Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation.在心力衰竭伴正常节律及心房颤动患者接受地高辛治疗的早期阶段，其红细胞中强心苷受体位点、铷⁸⁶摄取及细胞内钠浓度的变化。
Br J Clin Pharmacol. 1979 Aug;8(2):125-34. doi: 10.1111/j.1365-2125.1979.tb05810.x.
7
The plasma digoxin concentration, red cell rubidium 86 uptake and control of ventricular rate in patients being digitalized for artrial fibrilation.
Clin Sci. 1972 Jan;42(1):3P. doi: 10.1042/cs042003pa.
8
Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests.老年人及肾衰竭患者中的地高辛。红细胞86铷摄取试验的作用。
Eur J Cardiol. 1981;12(5):285-96.
9
Proceedings: The influence of digoxin metabolites on 86Rb-uptake of human erythrocytes.论文集：地高辛代谢产物对人红细胞摄取⁸⁶Rb的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1975;287 Suppl:R41.
引用本文的文献
1
David Grahame Grahame-Smith: clinical pharmacologist. 1933-2011.大卫·格雷厄姆·格雷厄姆-史密斯：临床药理学家。1933 - 2011年。
Br J Clin Pharmacol. 2012 May;73(5):830-2. doi: 10.1111/j.1365-2125.2011.04160.x.
2
Clinical pharmacokinetics of digoxin 1980.地高辛的临床药代动力学 1980 年
Clin Pharmacokinet. 1980 Mar-Apr;5(2):137-49. doi: 10.2165/00003088-198005020-00002.
3
The effect of digoxin on 86rubidium uptake by erythrocytes from mothers and babies.地高辛对母婴红细胞摄取86铷的影响。
Br J Clin Pharmacol. 1983 Jan;15(1):49-53. doi: 10.1111/j.1365-2125.1983.tb01462.x.
4
Familial abnormality of erythrocyte cation transport in essential hypertension.原发性高血压中红细胞阳离子转运的家族性异常。
Br Med J (Clin Res Ed). 1981 Apr 11;282(6271):1186-8. doi: 10.1136/bmj.282.6271.1186.
5
Measurement of specific [3H]-ouabain binding to different types of human leucocytes.测量特异性[³H]哇巴因与不同类型人类白细胞的结合。
Br J Clin Pharmacol. 1984 Aug;18(2):153-61. doi: 10.1111/j.1365-2125.1984.tb02447.x.
6
Erythrocytic cation transport receptor numbers and activity in pregnancies complicated by essential hypertension and pre-eclampsia.妊娠合并原发性高血压和先兆子痫时红细胞阳离子转运受体数量及活性
Br Med J (Clin Res Ed). 1984 May 5;288(6427):1332-4. doi: 10.1136/bmj.288.6427.1332.
7
Indications for the measurement of plasma digoxin concentrations.血浆地高辛浓度测定的适应证。
Drugs. 1983 Sep;26(3):230-42. doi: 10.2165/00003495-198326030-00004.
8
Techniques for studying the pharmacodynamic effects of cardiac glycosides on patients' own erythrocytes during glycoside therapy.在洋地黄苷治疗期间研究洋地黄苷对患者自身红细胞药效学作用的技术。
Klin Wochenschr. 1981 Dec 15;59(24):1323-32. doi: 10.1007/BF01720552.
9
Lack of effect of phenytoin on functions related to Na+,K+-ATPase activity of the intact erythrocytes of epileptic patients.苯妥英对癫痫患者完整红细胞中与钠钾ATP酶活性相关功能无影响。
Br J Clin Pharmacol. 1981 Jul;12(1):79-81. doi: 10.1111/j.1365-2125.1981.tb01858.x.
10
Clinical relevance of pharmacokinetics.药代动力学的临床相关性。
Clin Pharmacokinet. 1980 Mar-Apr;5(2):105-36. doi: 10.2165/00003088-198005020-00001.
本文引用的文献
1
AN ION TRANSPORT DEFECT IN ERYTHROCYTES FROM UREMIC PATIENTS.尿毒症患者红细胞中的离子转运缺陷。
Trans Assoc Am Physicians. 1964;77:169-81.
2
Changes in the erythrocyte potassium in patients with cardiac failure treated with digitalis.洋地黄治疗心力衰竭患者红细胞钾的变化。
Clin Chem. 1958 Aug;4(4):311-5.
3
[Cardiac glycosides as inhibitors of active potassium and sodium transport by erythrocyte membrane].[强心苷作为红细胞膜主动钾和钠转运的抑制剂]
Helv Physiol Pharmacol Acta. 1953;11(4):346-54.
4
5
Active transport of Rb86 in human red cells and rat brain slices.铷86在人红细胞和大鼠脑切片中的主动转运。
J Pharmacol Exp Ther. 1970 Aug;174(2):323-9.
6
Effect of digitalis on systolic time intervals in heart failure.洋地黄对心力衰竭患者收缩期时间间期的影响。
Am J Med Sci. 1970 Jan;259(1):4-20. doi: 10.1097/00000441-197001000-00002.
7
Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.采用放射免疫分析法测定治疗性和中毒性血清地高辛浓度。
N Engl J Med. 1969 Nov 27;281(22):1212-6. doi: 10.1056/NEJM196911272812203.
8
The isolation of digoxin-specific antibody and its use in reversing the effects of digoxin.地高辛特异性抗体的分离及其在逆转地高辛作用方面的应用。
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2401-6. doi: 10.1073/pnas.68.10.2401.
9
Plasma digoxin concentration--its relation to digoxin dosage and clinical effects in patients with atrial fibrillation.血浆地高辛浓度——心房颤动患者中其与地高辛剂量及临床疗效的关系
Br Heart J. 1972 Apr;34(4):383-91. doi: 10.1136/hrt.34.4.383.
10
Effect of digoxin on human red blood cell electrolytes.地高辛对人体红细胞电解质的影响。
Br J Pharmacol. 1972 Jan;44(1):165-7. doi: 10.1111/j.1476-5381.1972.tb07250.x.
Zotero 插件