在两名接受睾丸精子提取术以进行胞浆内单精子注射且手术成功的男性中发现了精原细胞瘤。

Seminoma discovered in two males undergoing successful testicular sperm extraction for intracytoplasmic sperm injection.

作者信息

Novero V, Goossens A, Tournaye H, Silber S, Van Steirteghem A C, Devroey P

机构信息

Center for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussels), Belgium.

出版信息

Fertil Steril. 1996 May;65(5):1051-4. doi: 10.1016/s0015-0282(16)58286-7.

DOI:10.1016/s0015-0282(16)58286-7

PMID:8612834

Abstract

OBJECTIVE

To describe two cases with testicular seminoma incidentally discovered at the time of successful testicular sperm extraction for intracytoplasmic sperm injection (ICSI)>

DESIGN

Report of two cases.

SETTING

Tertiary care academic center.

PATIENTS

Two males with nonobstructive azoospermia with history of cryptorchidism.

INTERVENTION

Testicular biopsy combined with ICSI; orchiectomy with radiotherapy.

RESULTS

From two couples and in three different cycles, 17 of 55 (31%) metaphase II oocytes fertilized after microinjection. Eleven of these fertilized oocytes cleaved normally and all 11 were replaced. One twin pregnancy was established and was delivered successfully later. In both cases, a seminoma was discovered at the time of testicular biopsy.

CONCLUSIONS

At the time of testicular biopsy for ICSI, a specimen for histopathology must be sent to exclude the presence of seminoma in males with nonobstructive azoospermia with a history of cryptorchidism. The effectiveness of testicular sperm extraction in combination with ICSI also has been demonstrated even against the background of testicular tumor.

摘要