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Passive immunization with antiserum to a nontoxic alpha-toxin mutant from Staphylococcus aureus is protective in a murine model.用针对金黄色葡萄球菌无毒α毒素突变体的抗血清进行被动免疫在小鼠模型中具有保护作用。
Infect Immun. 1996 May;64(5):1839-41. doi: 10.1128/iai.64.5.1839-1841.1996.
2
Functionally inactive S. aureus alpha-toxin containing a single amino acid substitution: potential usefulness as a vaccine.含有单个氨基酸取代的功能失活的金黄色葡萄球菌α毒素：作为疫苗的潜在用途。
Behring Inst Mitt. 1994 Dec(95):80-4.
3
Heterologous protection against alpha toxins of Clostridium perfringens and Staphylococcus aureus induced by binding domain recombinant chimeric protein.结合结构域重组嵌合蛋白诱导对产气荚膜梭菌和金黄色葡萄球菌α毒素的异源保护作用。
Vaccine. 2014 May 23;32(25):3075-81. doi: 10.1016/j.vaccine.2014.03.021. Epub 2014 Mar 31.
4
Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses.金黄色葡萄球菌分泌蛋白的免疫保护作用可使兔子免受严重疾病的侵害。
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5
Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model.金黄色葡萄球菌α-毒素基因的定点诱变：组氨酸在体外及小鼠模型中毒素活性中的作用
Infect Immun. 1994 May;62(5):1843-7. doi: 10.1128/iai.62.5.1843-1847.1994.
6
Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin.α毒素β孔道结构域中线性保护性中和表位的鉴定与验证
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7
Development of Combination Vaccine Conferring Optimal Protection against Six Pore-Forming Toxins of Staphylococcus aureus.开发组合疫苗以提供针对金黄色葡萄球菌六种孔形成毒素的最佳保护。
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Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.血液透析患者及金黄色葡萄球菌菌血症术后患者中α-毒素hla基因变体、α-毒素表达水平及α-毒素抗体水平的特征分析
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Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin.人源抗金黄色葡萄球菌α-溶血素抗体的作用机制及体内疗效。
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10
[Protective effects of active immunization against alpha hemolysin of Staphylococcus aureus].[金黄色葡萄球菌α溶血素主动免疫的保护作用]
Zentralbl Veterinarmed B. 1982 Sep;29(8):596-603.

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An Eye on Toxins: Roles in Ocular Damage and Inflammation.关注毒素：在眼损伤和炎症中的作用。
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Subinhibitory concentrations of tedizolid potently inhibit extracellular toxin production by methicillin-sensitive and methicillin-resistant Staphylococcus aureus.亚抑菌浓度的替加环素能有效抑制耐甲氧西林敏感和耐甲氧西林金黄色葡萄球菌的细胞外毒素产生。
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本文引用的文献

1
Laboratory and clinical evaluation of conjugate vaccines composed of Staphylococcus aureus type 5 and type 8 capsular polysaccharides bound to Pseudomonas aeruginosa recombinant exoprotein A.由金黄色葡萄球菌5型和8型荚膜多糖与铜绿假单胞菌重组外蛋白A结合而成的结合疫苗的实验室和临床评估。
Infect Immun. 1993 Mar;61(3):1023-32. doi: 10.1128/iai.61.3.1023-1032.1993.
2
Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model.金黄色葡萄球菌α-毒素基因的定点诱变：组氨酸在体外及小鼠模型中毒素活性中的作用
Infect Immun. 1994 May;62(5):1843-7. doi: 10.1128/iai.62.5.1843-1847.1994.
3
Functionally inactive S. aureus alpha-toxin containing a single amino acid substitution: potential usefulness as a vaccine.含有单个氨基酸取代的功能失活的金黄色葡萄球菌α毒素：作为疫苗的潜在用途。
Behring Inst Mitt. 1994 Dec(95):80-4.
4
Expression of a cloned Staphylococcus aureus alpha-hemolysin determinant in Bacillus subtilis and Staphylococcus aureus.克隆的金黄色葡萄球菌α-溶血素决定簇在枯草芽孢杆菌和金黄色葡萄球菌中的表达。
Infect Immun. 1983 Sep;41(3):1112-7. doi: 10.1128/iai.41.3.1112-1117.1983.
5
Staphylococcus aureus. The persistent pathogen (second of two parts).金黄色葡萄球菌。持续性病原体（两部分中的第二部分）
N Engl J Med. 1984 May 31;310(22):1437-42. doi: 10.1056/NEJM198405313102206.
6
Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement.通过等位基因置换分离的金黄色葡萄球菌蛋白A缺陷型和α-毒素缺陷型突变体的毒力。
Infect Immun. 1987 Dec;55(12):3103-10. doi: 10.1128/iai.55.12.3103-3110.1987.
7
Inactivation of the alpha-haemolysin gene of Staphylococcus aureus 8325-4 by site-directed mutagenesis and studies on the expression of its haemolysins.通过定点诱变使金黄色葡萄球菌8325 - 4的α-溶血素基因失活及其溶血素表达的研究
Microb Pathog. 1986 Apr;1(2):125-38. doi: 10.1016/0882-4010(86)90015-x.
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Staphylococcal alpha toxin promotes blood coagulation via attack on human platelets.葡萄球菌α毒素通过攻击人类血小板促进血液凝固。
J Exp Med. 1988 Aug 1;168(2):527-42. doi: 10.1084/jem.168.2.527.
9
Bacterial exotoxins and endothelial permeability for water and albumin in vitro.细菌外毒素与体外水和白蛋白的内皮通透性
Am J Physiol. 1988 Sep;255(3 Pt 1):C368-76. doi: 10.1152/ajpcell.1988.255.3.C368.
10
Assay of hemolytic toxins.溶血毒素测定
Methods Enzymol. 1988;165:213-7. doi: 10.1016/s0076-6879(88)65033-6.

用针对金黄色葡萄球菌无毒α毒素突变体的抗血清进行被动免疫在小鼠模型中具有保护作用。

Passive immunization with antiserum to a nontoxic alpha-toxin mutant from Staphylococcus aureus is protective in a murine model.

作者信息

Menzies B E, Kernodle D S

机构信息

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

出版信息

Infect Immun. 1996 May;64(5):1839-41. doi: 10.1128/iai.64.5.1839-1841.1996.

DOI:10.1128/iai.64.5.1839-1841.1996
PMID:8613399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174000/
Abstract

A nonhemolytic, nonlethal variant of Staphylococcus aureus alpha-toxin constructed via oligonucleotide-directed mutagenesis and containing a single amino acid substitution (H-35 to L) was used to immunize a rabbit. The resulting antiserum was cross-reactive with wild-type alpha-toxin and neutralized its hemolytic activity in vitro. Passive immunization of mice with rabbit antiserum conferred protection against lethal challenge with wild-type alpha-toxin and against acute lethal challenge with a high-alpha-toxin -producing S. aureus strain. H35L alpha-toxin may be useful as a protective immunogen in S. aureus vaccine studies.

摘要

通过寡核苷酸定向诱变构建的、含有单个氨基酸取代（H-35 变为 L）的金黄色葡萄球菌α毒素的非溶血、非致死变体被用于免疫一只兔子。所得抗血清与野生型α毒素交叉反应，并在体外中和其溶血活性。用兔抗血清对小鼠进行被动免疫可使其免受野生型α毒素的致死性攻击以及高α毒素产生的金黄色葡萄球菌菌株的急性致死性攻击。H35Lα毒素可能作为金黄色葡萄球菌疫苗研究中的保护性免疫原有用。