Pierce H I, Kurachi S, Sofroniadou K, Stamatoyannopoulos G
Blood. 1977 Jun;49(6):981-6.
The frequency of thalassemia was determined in a group of 541 healthy adult black males. Individuals with decreased mean corpuscular hemoglobin (MCH) values were evaluated further with hemoglobin analysis, iron studies, and globin chain synthesis. Of the males screened, 13.4% had MCH levels below 27.0 pg, while 1.4% had heterozygous beta thalassemia, 2.3% had iron deficiency, and 5.7% had globin synthesis findings compatible with the diagnosis of alpha thalassemia trait (alpha thalassemia-1). This study suggests that thalassemia is one of the most frequent hematologically depictable abnormalities in American blacks.
在一组541名健康成年黑人男性中测定了地中海贫血的发病率。对平均红细胞血红蛋白（MCH）值降低的个体进一步进行血红蛋白分析、铁代谢研究和珠蛋白链合成检测。在筛查的男性中，13.4%的人MCH水平低于27.0 pg，而1.4%的人患有杂合子β地中海贫血，2.3%的人缺铁，5.7%的人珠蛋白合成结果符合α地中海贫血特征（α地中海贫血-1）的诊断。这项研究表明，地中海贫血是美国黑人中最常见的血液学可描述异常之一。
