Cribier B, Gambini C, Rainero M, Grosshans E
Clinic of Dermatology, Strasbourg, France.
Acta Derm Venereol. 1995 Sep;75(5):337-9. doi: 10.2340/0001555575337339.
Multinucleate cell angiohistiocytoma (MCA) was first characterized by Smith & Wilson-Jones. Although only a few cases have been published, this very characteristic benign tumor is probably not rare. The clinical pictures are firm circumscribed papules, mainly of the hands, which progress slowly over the years. The histologic features show an increase of capillaries and venules in the reticular dermis, overlaid by epidermal hyperplasia. Bizarre-shaped multinucleate cells are present between the vessels, and factor XIIIa-positive interstitial cells are increased in number. MCA can be easily recognised if the pathologist is aware of the diagnosis. We present here the clinical, histologic and immunopathologic features of 4 new cases and review the literature.
多核细胞血管组织细胞瘤（MCA）最初由史密斯和威尔逊 - 琼斯描述。尽管仅有少数病例发表，但这种极具特征性的良性肿瘤可能并不罕见。临床表现为边界清楚的坚实丘疹，主要发生于手部，多年来进展缓慢。组织学特征显示网状真皮层内毛细血管和小静脉增多，上方伴有表皮增生。血管之间可见形态怪异的多核细胞，且因子ⅩⅢa阳性的间质细胞数量增加。如果病理学家了解其诊断，MCA很容易识别。我们在此呈现4例新病例的临床、组织学和免疫病理特征并复习相关文献。
