Kannel W B, D'Agostino R B, Cobb J L
Department of Medicine, Section of Preventative Medicine and Epidemiology, Boston University, Framingham Heart Study, MA 01701, USA.
Am J Clin Nutr. 1996 Mar;63(3 Suppl):419S-422S. doi: 10.1093/ajcn/87.6.1602.
Involuntary weight gains worsen all elements of the cardiovascular risk profile, including dyslipidemia, hypertension, insulin-resistant glucose intolerance, left-ventricular hypertrophy, hyperuricemia, and elevated fibrinogen. On the basis of data from the Framingham Heart Study and from other studies, it can be concluded that the degree of overweight is related to the rate of development of cardiovascular disease. After 26 y of follow-up in the Framingham study, each SD increment in relative weight was associated with 15% and 22% increases in cardiovascular events in men and women, respectively. Avoidance of weight gain after the age of 25 y is advisable to reduce cardiovascular mortality. There is a great potential benefit to weight loss, suggesting that weight control as a means for preventing and lessening cardiovascular disease become a national health priority. The optimal weight for avoidance of cardiovascular disease and prolonging life corresponds to a body mass index of 22.6 for men and 21.1 for women.
非自愿性体重增加会使心血管风险状况的所有因素恶化，包括血脂异常、高血压、胰岛素抵抗性葡萄糖不耐受、左心室肥厚、高尿酸血症和纤维蛋白原升高。根据弗雷明汉心脏研究及其他研究的数据，可以得出结论，超重程度与心血管疾病的发展速度相关。在弗雷明汉研究进行26年随访后，相对体重每增加1个标准差，男性和女性心血管事件分别增加15%和22%。建议25岁后避免体重增加以降低心血管疾病死亡率。减肥有很大的潜在益处，这表明将控制体重作为预防和减轻心血管疾病的手段应成为国家卫生重点。避免心血管疾病和延长寿命的最佳体重对应的男性体重指数为22.6，女性为21.1。
