Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2C9, Canada.
Nutrients. 2021 Sep 30;13(10):3476. doi: 10.3390/nu13103476.
There is substantial overlap in risk factors for the pathogenesis and progression of breast cancer (BC) and cardiovascular disease (CVD), including obesity, metabolic disturbances, and chronic inflammation. These unifying features remain prevalent after a BC diagnosis and are exacerbated by BC treatment, resulting in elevated CVD risk among survivors. Thus, therapies that target these risk factors or mechanisms are likely to be effective for the prevention or progression of both conditions. In this narrative review, we propose time-restricted eating (TRE) as a simple lifestyle therapy to address many upstream causative factors associated with both BC and CVD. TRE is simple dietary strategy that typically involves the consumption of ad libitum energy intake within 8 h, followed by a 16-h fast. We describe the feasibility and safety of TRE and the available evidence for the impact of TRE on metabolic, cardiovascular, and cancer-specific health benefits. We also highlight potential solutions for overcoming barriers to adoption and adherence and areas requiring future research. In composite, we make the case for the use of TRE as a novel, safe, and feasible intervention for primary and secondary BC prevention, as well as tertiary prevention as it relates to CVD in BC survivors.
乳腺癌（BC）和心血管疾病（CVD）的发病机制和进展存在大量共同的危险因素，包括肥胖、代谢紊乱和慢性炎症。这些共同的特征在 BC 诊断后仍然普遍存在，并因 BC 治疗而加剧，导致幸存者的 CVD 风险升高。因此，针对这些危险因素或机制的治疗方法可能对预防或治疗这两种疾病都有效。在这篇叙述性综述中，我们提出限时进食（TRE）作为一种简单的生活方式疗法，以解决与 BC 和 CVD 相关的许多上游致病因素。TRE 是一种简单的饮食策略，通常包括在 8 小时内随意摄入能量，然后禁食 16 小时。我们描述了 TRE 的可行性和安全性，以及 TRE 对代谢、心血管和癌症特异性健康益处的现有证据。我们还强调了克服采用和坚持障碍的潜在解决方案，以及需要进一步研究的领域。总之，我们认为 TRE 可作为一种新的、安全且可行的干预措施，用于 BC 的一级和二级预防，以及与 BC 幸存者 CVD 相关的三级预防。
