Larson H E, Parry J V, Price A B, Davies D R, Dolby J, Tyrrell D A
Br Med J. 1977 May 14;1(6071):1246-8. doi: 10.1136/bmj.1.6071.1246.
A girl aged 12 developed pseudomembranous colitis after a short course of oral penicillin. She had no history of adverse reaction to penicillin before or after the illness. No pathogenic bacteria, mycoplasmas, or viruses were found in her faeces, but they did contain a toxin. Toxin was also found in four of five other patients with pseudomembranous colitis but not in six specimens obtained from patients with diarrhoea caused by other disorders. Further studies may show that pseudomembranous colitis is caused by a bacterial toxin.
一名12岁女孩在短期口服青霉素后患上了伪膜性结肠炎。她在患病前后均无青霉素不良反应史。其粪便中未发现病原菌、支原体或病毒，但确实含有一种毒素。在其他5例伪膜性结肠炎患者中，有4例的粪便中也发现了毒素，而在6例由其他疾病引起腹泻的患者的样本中则未发现。进一步的研究可能会表明，伪膜性结肠炎是由一种细菌毒素引起的。
