Manto M, Preiser J C, Vincent J L
Erasme University Hospital, Free University of Brussels, Belgium.
J Toxicol Clin Toxicol. 1996;34(2):205-8. doi: 10.3109/15563659609013771.
Diphenylhydantoin, a widely used antiepileptic agent, can alter carbohydrate tolerance, and acute intoxication with diphenylhydantoin can be associated with hyperglycemia.
We describe a patient who experienced a prolonged episode of hypoglycemia secondary to an acute voluntary intoxication with diphenylhydantoin 20 g and zopiclone 225 mg. This hypoglycemic episode was presumptively attributed to diphenylhydantoin and might be due either to an escape from the inhibitory effects of diphenylhydantoin on insulin secretion or an increased sensitivity of the tissues to insulin. Zopiclone was considered less likely since zopiclone overdoses have been only exceptionally associated with hyperglycemia.
苯妥英钠是一种广泛使用的抗癫痫药物，可改变糖耐量，苯妥英钠急性中毒可能与高血糖有关。
我们描述了一名患者，该患者因自愿急性服用20克苯妥英钠和225毫克佐匹克隆而经历了长时间的低血糖发作。这一低血糖发作据推测归因于苯妥英钠，可能是由于苯妥英钠对胰岛素分泌的抑制作用消失，或者是组织对胰岛素的敏感性增加。佐匹克隆被认为可能性较小，因为佐匹克隆过量仅在极少数情况下与高血糖有关。
