与一例罕见溺水病例相关的催眠药佐匹克隆的检测与定量分析。

Detection and quantification of the hypnotic zopiclone, connected with an uncommon case of drowning.

作者信息

Mannaert E, Tytgat J, Daenens P

机构信息

Laboratory of Toxicology, Katholieke Universiteit Leuven, Belgium.

出版信息

Forensic Sci Int. 1996 Nov 11;83(1):67-72. doi: 10.1016/0379-0738(96)02018-x.

DOI:10.1016/0379-0738(96)02018-x

PMID:8939015

Abstract

A fatality, attributed to a suicidal ingestion of zopiclone and subsequent death by drowning, is described. A radioimmunoassay was performed to prescreen for the presence of the analyte. HPLC analysis with fluorescence detection demonstrated a testicular tissue concentration of 2.2 micrograms/g zopiclone. Further toxicological analysis revealed also the presence of diazepam in a concentration of 150 ng/g.

摘要

描述了一例因自杀性摄入佐匹克隆并随后溺水死亡的案例。进行了放射免疫分析以预筛分析物的存在。采用荧光检测的高效液相色谱分析表明，睾丸组织中佐匹克隆的浓度为2.2微克/克。进一步的毒理学分析还显示存在浓度为150纳克/克的地西泮。