Garcia A, Fulton J E
Dermatol Surg. 1996 Jan;22(1):39-43. doi: 10.1111/j.1524-4725.1996.tb00569.x.
Botulinum toxin has been used for facial hemispasm, strabismus, and blepharospasm. Recently it has been advocated to treat the frown lines. We have extended this program to treatment of other muscles of facial expression.
Botulinum toxin is injected into the muscles of facial expression in two or three sessions to produce a temporary loss of muscle tone. A standard method of cooling, injection, and compression was developed to minimize pain and bruising.
To complete a dose-response study to document the optimum timing and amount of toxin needed for each muscle group.
Two to five Botulinum toxin units per muscle was as adequate as higher doses. Toxin that was reconstituted 30 days earlier produced the same loss of muscle tone as freshly mixed toxin. With two or three injection sessions loss of muscle tone lasted for up to 1 year.
Botulinum toxin is highly effective as an adjuvant therapy for facial rejuvenation. This minor surgical procedure can temporarily reduce the lines on the upper face and produce a pleasing effect. With proper dosing and dilution this rejuvenation program becomes cost effective.
肉毒杆菌毒素已被用于治疗面部痉挛、斜视和眼睑痉挛。最近有人主张用其治疗皱眉纹。我们已将该方案扩展至治疗其他面部表情肌。
分两到三次将肉毒杆菌毒素注射到面部表情肌中，以使肌肉张力暂时丧失。开发了一种标准的冷却、注射和按压方法，以尽量减少疼痛和瘀伤。
完成一项剂量反应研究，以记录每个肌肉群所需毒素的最佳时间和剂量。
每块肌肉注射2至5个肉毒杆菌毒素单位与更高剂量同样有效。提前30天复溶的毒素产生的肌肉张力丧失与新鲜混合的毒素相同。经过两到三次注射，肌肉张力丧失可持续长达1年。
肉毒杆菌毒素作为面部年轻化的辅助治疗非常有效。这种小手术可暂时减少上脸皱纹并产生令人满意的效果。通过适当的给药和稀释，这种年轻化方案具有成本效益。
