Davignon J, Lussier-Cacan S, Ortin-George M, Lelièvre M, Bertagna C, Gattereau A, Fontaine A
Can Med Assoc J. 1977 Jun 4;116(11):1245-50.
The prevalence and type of plasma lipoprotein abnormalities were determined in 114 French-Canadian patients with angiographically proven peripheral vascular disease (PVD). The severity of atherosclerosis was positively correlated with plasma triglyceride concentration, especially in the younger patients (r = 0.29, P less than 0.05), and (not significantly) with plasma cholesterol concentration. Of the risk factors believed to predispose individuals to atherosclerosis, cigarette smoking was the most frequently found in the PVD patients (72.8%), especially among the men. Combination of two or more risk factors was the rule. Findings were compared with those in 114 patients who had undergone coronary angiography for suspected coronary heart disease (CHD). The CHD patients were, on average, younger by 10 years. Hyperlipidemia was present in 58.8% of CHD patients, compared with 43.9% of PVD patients. A far higher proportion of CHD patients showed the type II plasma lipoprotein pattern (24.6% v. 7.9%), although the type IV pattern was more common in both groups (31.6% and 28.9%, respectively). A high proportion of all patients (56.1% with PVD and 41.2% with CHD) showed a normal lipoprotein pattern on paper electrophoresis.
对114例经血管造影证实患有外周血管疾病（PVD）的法裔加拿大患者的血浆脂蛋白异常的患病率和类型进行了测定。动脉粥样硬化的严重程度与血浆甘油三酯浓度呈正相关，尤其是在较年轻的患者中（r = 0.29，P < 0.05），与血浆胆固醇浓度（无显著相关性）。在被认为易患动脉粥样硬化的危险因素中，吸烟在PVD患者中最为常见（72.8%），尤其是在男性中。两种或更多危险因素并存是常见情况。将这些结果与114例因疑似冠心病（CHD）接受冠状动脉造影的患者的结果进行了比较。冠心病患者平均年龄小10岁。冠心病患者中高脂血症的发生率为58.8%，而PVD患者为43.9%。冠心病患者中显示II型血浆脂蛋白模式的比例要高得多（24.6%对7.9%），尽管IV型模式在两组中更为常见（分别为31.6%和28.9%）。所有患者中有很大比例（PVD患者为56.1%，CHD患者为41.2%）在纸上电泳时显示脂蛋白模式正常。
