Frick M H, Dahlén G, Berg K, Valle M, Hekali P
Chest. 1978 Jan;73(1):62-5. doi: 10.1378/chest.73.1.62.
Cholesterol, triglycerides, and Lp(a)/pre-beta1 lipoprotein were analyzed in 153 patients typed for liproprotien patterns. Coronary atherosclerosis was determined by selective coronary angiography and graded by a system taking into account proximal, middle and distal segments. Smoking habits, family history and hypertension were also recorded. Normal coronary arteries were encountered in 45, moderate coronary atherosclerosis (less than median score) in 50, and severe changes (greater than median score) in 58 patients. Cholesterol (P less than 0.05), positivity of Lp (a)/pre-beta1 lipoprotein (P less than 0.01), a family history of coronary heart disease (P less than 0.05), and smoking (P less than 0.01) differed between the group of normal arteries and the whole group of luminal obstructions. Serum triglycerides were not associated with coronary atherosclerosis. Cholesterol, positivity of the Lp(a)/pre-beta1 lipoprotein and a family history of coronary heart disease were also associated with the severity of the disease. Smoking was less prevalent in the group with severe changes.
对153例已确定脂蛋白模式的患者进行了胆固醇、甘油三酯和Lp(a)/前β1脂蛋白分析。通过选择性冠状动脉造影确定冠状动脉粥样硬化，并采用一种考虑近端、中段和远端节段的系统进行分级。还记录了吸烟习惯、家族史和高血压情况。45例患者冠状动脉正常，50例患者有中度冠状动脉粥样硬化（低于中位数评分），58例患者有严重病变（高于中位数评分）。正常动脉组与整个管腔阻塞组之间，胆固醇（P<0.05）、Lp(a)/前β1脂蛋白阳性（P<0.01）、冠心病家族史（P<0.05）和吸烟（P<0.01）存在差异。血清甘油三酯与冠状动脉粥样硬化无关。胆固醇、Lp(a)/前β1脂蛋白阳性和冠心病家族史也与疾病严重程度相关。在病变严重的组中吸烟的情况较少见。
