编码大肠杆菌中红霉素2'-磷酸转移酶I的红霉素抗性决定子的核苷酸序列及特性
Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli.
作者信息
Noguchi N, Emura A, Matsuyama H, O'Hara K, Sasatsu M, Kono M
机构信息
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
出版信息
Antimicrob Agents Chemother. 1995 Oct;39(10):2359-63. doi: 10.1128/AAC.39.10.2359.
Abstract
The DNA fragment (3.3 kb) containing the erythromycin resistance determinant was cloned from Escherichia coli Tf481A and sequenced. Deletion and complementation analyses indicated that the expression of high-level resistance to erythromycin requires two genes, mphA and mrx, which encode macrolide 2'-phosphotransferase I and an unidentified hydrophobic protein, respectively.
摘要
从大肠杆菌Tf481A中克隆出含有红霉素抗性决定簇的DNA片段（3.3 kb）并进行测序。缺失和互补分析表明，对红霉素的高水平抗性表达需要两个基因，即mphA和mrx，它们分别编码大环内酯2'-磷酸转移酶I和一种未知的疏水蛋白。
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