Tsai C C, Chen K S
Graduate Institute of Dental Sciences Kaohsiung Medical College, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1995 May;11(5):265-73.
Gingivitis is one of the most common oral diseases. It is caused by dental plaque and by the factors produced/released from it. The black pigmented bacteria in subgingival dental plaque are thought to be the periodontopathogens. Prevotella intermedia and Porphyromonas gingivalis have been shown to be closely associated with human gingivitis. Prevetella intermedia can use female sex hormones such as progesterone or estradiol as a source of nutrients. In pregnant women, the concentrations of progesterone and estradiol are markedly increased in serum and both are accumulated and found in the gingival tissue. The purpose of this study was to test levels of female sex hormones in gingival crevicular fluid and to observe the relationship between hormones and black pigmented bacteria in subgingival plaque. The results showed that the amount of progesterone found in the gingival crevicular fluid and percentage of black pigmented bacteria in subgingival plaque of pregnant women were markedly higher than in the postpartum stage. The percentage of black pigmented bacteria was positively correlated with the progesterone level, pregnancy and the severity of the gingivitis. Severity of the gingivitis was positively correlated with both the plaque index and the percentage of black pigmented bacteria in subgingival plaque.
牙龈炎是最常见的口腔疾病之一。它由牙菌斑及其产生/释放的因素引起。龈下牙菌斑中的黑色色素沉着菌被认为是牙周病原体。中间普氏菌和牙龈卟啉单胞菌已被证明与人类牙龈炎密切相关。中间普氏菌可以利用孕酮或雌二醇等女性性激素作为营养来源。在孕妇中，血清中孕酮和雌二醇的浓度显著升高，且二者都在牙龈组织中蓄积。本研究的目的是检测龈沟液中女性性激素的水平，并观察激素与龈下菌斑中黑色色素沉着菌之间的关系。结果显示，孕妇龈沟液中孕酮的含量以及龈下菌斑中黑色色素沉着菌的百分比明显高于产后阶段。黑色色素沉着菌的百分比与孕酮水平、妊娠及牙龈炎的严重程度呈正相关。牙龈炎的严重程度与菌斑指数以及龈下菌斑中黑色色素沉着菌的百分比均呈正相关。
