Scofield R H, Henry W E, Kurien B T, James J A, Harley J B
Immunology and Arthritis Program, Oklahoma Medical Research Foundation, Oklahoma City 73014, USA.
J Immunol. 1996 May 15;156(10):4059-66.
Systemic lupus erythematosus is characterized by the production of Abs to ribonucleoproteins, including Ro (or SS-A) and La (or SS-B). The mechanism by which these autoantibodies arise is unknown. We have immunized rabbits with peptides from the sequence of the 60-kDa Ro. Animals so immunized not only produce Abs to the immunogen peptide, but also develop an autoimmune response to the entire 60-kDa Ro Ag. In about 20% of these animals, autoimmunity also spreads to the La Ag. Anti-native DNA was present in one of nine rabbits. All animals had anti-nuclear Ab, but even among those immunized with the same peptides, different patterns of immunofluorescence were found. Thus, among these outbred animals immunized with peptides from 60-kDa Ro, distinct serologic manifestations were present, showing heterogeneity in the development of autoimmunity.
系统性红斑狼疮的特征是产生针对核糖核蛋白的自身抗体，包括Ro（或SS - A）和La（或SS - B）。这些自身抗体产生的机制尚不清楚。我们用来自60 kDa Ro序列的肽免疫兔子。如此免疫的动物不仅产生针对免疫原性肽的抗体，还对整个60 kDa Ro抗原产生自身免疫反应。在大约20%的这些动物中，自身免疫也扩散到La抗原。九只兔子中有一只存在抗天然DNA。所有动物都有抗核抗体，但即使在用相同肽免疫的动物中，也发现了不同的免疫荧光模式。因此，在用60 kDa Ro的肽免疫的这些远交动物中，存在明显的血清学表现，显示出自身免疫发展的异质性。
