孕期免疫复合物吞噬作用增强。
Enhanced phagocytosis of immune complexes in pregnancy.
作者信息
Rosenthal M
出版信息
Clin Exp Immunol. 1977 Apr;28(1):189-91.
Utilizing an in vitro immunofluorescence phagocytosis assay for the detection of circulating immune complexes sera from pregnant women, from women taking contraceptive agents and age-matched controls were tested for their effect on the phagocytosis of immune complexes by normal peripheral blood polymorphonuclear leucocytes (PMN). Immune complexes present in the serum of a patient with seropositive rheumatoid arthritis and heat-aggregated IgG (COHN fraction II) were used as substrate. A significant enhancement of the phagocytosis of immune complexes by PMN in the presence of increasing amounts of pregnancy serum was seen using rheumatoid arthritis serum as well as heat-aggregated IgG. Serum from patients taking contraceptive drugs and controls showed no effect on the phagocytosis of such complexes in vitro. These observations suggest that pregnancy serum contains factors which enhance the phagocytosis of immune complexes possibly resulting in an increased clearance of such complexes. The commonly seen improvement of rheumatic diseases in the course of pregnancy might at least partially be due to this mechanism.
利用体外免疫荧光吞噬试验检测循环免疫复合物，对孕妇、服用避孕药的女性以及年龄匹配的对照者的血清进行检测，以观察其对正常外周血多形核白细胞（PMN）吞噬免疫复合物的影响。血清学阳性类风湿性关节炎患者血清中的免疫复合物以及热聚集IgG（科恩II组分）用作底物。使用类风湿性关节炎血清以及热聚集IgG时，发现随着孕妇血清量增加，PMN对免疫复合物的吞噬作用显著增强。服用避孕药的患者血清和对照血清在体外对这类复合物的吞噬作用无影响。这些观察结果表明，孕妇血清中含有增强免疫复合物吞噬作用的因子，这可能导致这类复合物的清除增加。妊娠期常见的风湿性疾病病情改善可能至少部分归因于这一机制。
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