为什么某些蛋白质结构如此常见？
Why are some proteins structures so common?
作者信息
Govindarajan S, Goldstein R A
机构信息
Department of Chemistry, University of Michigan, Ann Arbor 48109-1055, USA.
出版信息
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3341-5. doi: 10.1073/pnas.93.8.3341.
Abstract
Many biological proteins are observed to fold into one of a limited number of structural motifs. By considering the requirements imposed on proteins by their need to fold rapidly, and the ease with which such requirements can be fulfilled as a function of the native structure, we can explain why certain structures are repeatedly observed among proteins with negligible sequence similarity. This work has implications for the understanding of protein sequence structure relationships as well as protein evolution.
摘要
许多生物蛋白质被观察到折叠成数量有限的几种结构基序之一。通过考虑蛋白质快速折叠的需求所带来的限制，以及这些需求作为天然结构的函数得以满足的难易程度，我们可以解释为什么在序列相似性可忽略不计的蛋白质中会反复观察到某些结构。这项工作对于理解蛋白质序列 - 结构关系以及蛋白质进化具有重要意义。
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