Gottlow J, Nyman S
Guidor Research Center, Göteborg, Sweden.
Curr Opin Periodontol. 1996;3:140-8.
Efficacious guided tissue regeneration for intrabony, furcation class II, and recession defects can be accomplished with both nonresorbable and bioresorbable barriers. The potential for regeneration of the periodontium is highly dependent on defect morphology and the availability of "progenitor cells." Many factors associated with surgical technique and barrier properties influence the regenerative outcome of guided tissue regeneration. Maintained flap coverage of the barrier minimizes epithelial down-growth as well as the risk of bacterial contamination of the barrier and the healing wound. Coverage of the newly regenerated tissues after removal of nonresorbable barriers is essential. The use of bioresorbable barriers eliminates a second operation for membrane removal and the associated potential trauma to the regenerating tissues. A stringent postoperative plaque control regimen is necessary during the healing period. The use of systemic antibiotics, prescribed concomitantly with insertion of the barriers has limited effect in controlling various pathogens and is therefore questionable.
使用不可吸收和可生物吸收屏障均可实现对骨内、Ⅱ度根分叉和牙龈退缩缺损的有效引导组织再生。牙周组织的再生潜力高度依赖于缺损形态和“祖细胞”的可用性。许多与手术技术和屏障特性相关的因素会影响引导组织再生的再生效果。保持屏障的瓣覆盖可最大限度地减少上皮向下生长以及屏障和愈合伤口受到细菌污染的风险。去除不可吸收屏障后对新再生组织的覆盖至关重要。使用可生物吸收屏障可避免进行第二次去除膜的手术以及对再生组织的相关潜在创伤。在愈合期必须采取严格的术后菌斑控制方案。与屏障植入同时开具的全身性抗生素在控制各种病原体方面效果有限，因此存在疑问。
