Hermann J S, Buser D
University of Texas Health Science Center at San Antonio, USA.
Curr Opin Periodontol. 1996;3:168-77.
The application of barrier membranes to promote bone regeneration was first described by Hurley et al. (J Bone Joint Surg 1959, 41A:1243-1254) in orthopedic research. However, the clinical potential of this membrane technique was recognized in the early 1980s for periodontal regeneration. Based on promising results in periodontology, researchers started to evaluate the potential of this technique--often called guided bone regeneration (GBR)--to regenerate bone defects in the alveolar process. This review describes the current knowledge of GBR in implant dentistry. Emphasis is placed on the scientific basis of GBR and the various surgical factors necessary to achieve predictable results with GBR procedures. In addition, unanswered questions that require future research are addressed including long-term success rates of dental implants placed in combination with barrier membranes, evaluation of resorbable membranes, and use of bone substitutes or growth factors to enhance bone regeneration in membrane-protected defects.
屏障膜促进骨再生的应用最早由赫尔利等人（《骨与关节外科杂志》1959年，41A:1243 - 1254）在骨科研究中描述。然而，这种膜技术的临床潜力在20世纪80年代初被认识到可用于牙周再生。基于牙周病学方面的良好结果，研究人员开始评估这种技术——通常称为引导骨再生（GBR）——在牙槽突骨缺损再生中的潜力。本综述描述了种植牙科中GBR的当前知识。重点在于GBR的科学基础以及通过GBR程序获得可预测结果所需的各种手术因素。此外，还讨论了需要未来研究的未解决问题，包括与屏障膜联合植入的牙种植体的长期成功率、可吸收膜的评估以及使用骨替代物或生长因子来增强膜保护缺损中的骨再生。
