阴茎癌中 Epstein-Barr 病毒缺失。应用原位杂交技术对 42 例病例的研究。
Absence of Epstein-Barr virus in penile carcinoma. A study of 42 cases using in situ hybridization.
作者信息
Lam K Y, Chan A C, Chan K W, Leung M L, Srivastava G
机构信息
Department of Pathology, Queen Mary Hospital, Hong Kong.
出版信息
Cancer. 1995 Aug 15;76(4):658-60. doi: 10.1002/1097-0142(19950815)76:4<658::aid-cncr2820760418>3.0.co;2-b.
BACKGROUND
The relationship between Epstein-Barr virus (EBV) and carcinomas of the lower female genital tract has been the focus of some studies in recent years. However, the association between EBV and penile carcinoma never has been investigated. The aim of this study was to identify the possible role of EBV in penile carcinoma of Chinese patients.
METHODS
Formalin fixed, paraffin embedded tissue of 42 cases of penile carcinoma (including 7 verrucous, 14 well differentiated, 15 moderately differentiated, and 6 poorly differentiated squamous cell carcinomas), 6 penile warts, and 9 normal penile samples were analyzed for EBV using in situ hybridization for EBV-encoded RNA (EBER).
RESULTS
Epstein-Barr virus was only found in a few lymphocytes adjacent to the tumor epithelium in 12% (5 cases) of penile carcinoma. Conversely, the tumor cells, penile warts, and normal penile tissue were negative for EBV.
CONCLUSIONS
The results suggest that EBV does not play a major role in the etiology of penile carcinoma.
背景
近年来，爱泼斯坦-巴尔病毒（EBV）与女性下生殖道癌之间的关系一直是一些研究的重点。然而，EBV与阴茎癌之间的关联从未被研究过。本研究的目的是确定EBV在中国阴茎癌患者中可能发挥的作用。
方法
采用原位杂交检测EBV编码RNA（EBER），对42例阴茎癌（包括7例疣状、14例高分化、15例中分化和6例低分化鳞状细胞癌）、6例阴茎疣和9例正常阴茎组织的福尔马林固定石蜡包埋组织进行EBV分析。
结果
仅在12%（5例）的阴茎癌中，在肿瘤上皮附近的少数淋巴细胞中发现了爱泼斯坦-巴尔病毒。相反，肿瘤细胞、阴茎疣和正常阴茎组织的EBV检测均为阴性。
结论
结果表明，EBV在阴茎癌的病因学中不发挥主要作用。
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