肺淋巴上皮瘤样癌：两例爱泼斯坦-巴尔病毒感染分析

Lymphoepithelioma-like carcinoma of the lung: analysis of two cases for Epstein-Barr virus infection.

作者信息

Higashiyama M, Doi O, Kodama K, Yokouchi H, Tateishi R, Horiuchi K, Mishima K

机构信息

Department of Thoracic Surgery, Center for Adult Diseases, Osaka, Japan.

出版信息

Hum Pathol. 1995 Nov;26(11):1278-82. doi: 10.1016/0046-8177(95)90206-6.

DOI:10.1016/0046-8177(95)90206-6

PMID:7590705

Abstract

Lymphoepithelioma-like carcinoma, which is an uncommon histological type of epithelial tumor, has been described as being closely associated with Epstein-Barr virus (EBV) infection in organs other than the lung. Recently, we experienced two surgically resected cases of pulmonary tumors mimicking lymphoepithelioma-like carcinoma. Both cases contained EBV DNA genomes as shown by polymerase chain reaction (PCR) using EBV DNA-specific primers, one positive for EBV DNA in virtually all cancer cells, and the other showing positive hybridization in a small number of cancer cells by in situ hybridization (ISH) using digoxigenin-labeled olignucletide probes for each of EBV DNA for EBV DNA. EBV-encoded RNA-1 (EBER-1) was typically detected in one case. These results are highly suggestive of EBV-associated tumors in one of the current cases, although in the other case, no such close association was determined. It seems that lymphoepithelioma-like pulmonary carcinoma, which seems extremely unusual, may be closely associated with EBV infection in tumorigenesis.

摘要

淋巴上皮瘤样癌是一种罕见的上皮性肿瘤组织学类型，在肺部以外的器官中已被描述为与爱泼斯坦-巴尔病毒（EBV）感染密切相关。最近，我们遇到了两例手术切除的类似淋巴上皮瘤样癌的肺肿瘤病例。两例病例均含有EBV DNA基因组，这通过使用EBV DNA特异性引物的聚合酶链反应（PCR）得以显示，其中一例几乎所有癌细胞中的EBV DNA均呈阳性，另一例通过使用地高辛标记的寡核苷酸探针针对EBV DNA进行原位杂交（ISH），在少数癌细胞中显示出阳性杂交。在其中一例病例中典型地检测到了EBV编码的RNA-1（EBER-1）。这些结果强烈提示当前病例中的其中一例为EBV相关肿瘤，尽管在另一例病例中未确定存在如此紧密的关联。看起来极为罕见的淋巴上皮瘤样肺癌在肿瘤发生过程中可能与EBV感染密切相关。