乳腺癌中爱泼斯坦-巴尔病毒的原位检测

In situ detection of Epstein-Barr virus in breast cancer.

作者信息

Chu J S, Chen C C, Chang K J

机构信息

Department of Pathology, College of Medicine, National Taiwan University, Taipei.

出版信息

Cancer Lett. 1998 Feb 13;124(1):53-7. doi: 10.1016/s0304-3835(97)00449-7.

DOI:10.1016/s0304-3835(97)00449-7

PMID:9500191

Abstract

Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.

摘要

爱泼斯坦-巴尔病毒（EBV）与鼻咽癌以及其他解剖部位的一些淋巴上皮瘤样癌密切相关。本研究调查了EBV在乳腺癌中的存在情况。对60例浸润性乳腺癌进行了EBV蛋白（EBV核抗原-2和潜伏膜蛋白-1）的免疫组织化学检测以及EBV编码的小核RNA（EBER-1和-2）的原位杂交检测。60例乳腺癌样本中均未检测到EBV。这些结果表明，EBV可能在台湾地区乳腺癌的病因学中不起重要作用。