Akervall J A, Jin Y, Wennerberg J P, Zätterström U K, Kjellén E, Mertens F, Willén R, Mandahl N, Heim S, Mitelman F
Department of Otorhinolaryngology, University Hospital, Lund, Sweden.
Cancer. 1995 Sep 1;76(5):853-9. doi: 10.1002/1097-0142(19950901)76:5<853::aid-cncr2820760520>3.0.co;2-6.
In individual patients with squamous cell carcinoma of the head and neck (SCCHN), established prognostic factors do not satisfactorily predict clinical outcome. Although the karyotype is an independent prognostic factor in certain hematologic malignancies and solid tumors, no data have been reported concerning the possible relationship between chromosomal abnormalities and clinical outcome in patients with SCCHN:
In 116 cases of primary SCCHN, short term cultures were analyzed cytogenetically during 1987 through 1991, the karyotypes were divided into four groups: k1, normal (n = 35); k2, numeric changes only (n = 31); k3, simple structural abnormalities (n = 27); and k4, complex karyotypes (n = 23). The patients were followed for at least 18 months after diagnosis or until death.
The 2-year survival rate was lower in the k4 subgroup (35%) than in the k1, k2, and k3 subgroups taken together (61%), both in the series as a whole (P = 0.02), and in the largest tumor site subgroup, laryngeal squamous cell carcinoma (n = 32), (P = 0.04). The most prevalent breakpoint was in chromosome band 11q13, occurring in 11 tumors, 10 of which belonged to the k4-subgroup. The 2-year survival rate was lower for patients with 11q13 rearrangements (20%) than for those without (60%), both in the series as a whole (P = 0.001), and in the k4-subgroup (P = 0.02).
The results suggest that in SCCHN the presence of a complex karyotype is associated with poor prognosis, particularly when 11q13 rearrangements are present.
在头颈部鳞状细胞癌（SCCHN）个体患者中，既定的预后因素不能令人满意地预测临床结局。虽然核型在某些血液系统恶性肿瘤和实体瘤中是独立的预后因素，但尚无关于SCCHN患者染色体异常与临床结局之间可能关系的报道。
1987年至1991年期间，对116例原发性SCCHN进行了细胞遗传学短期培养分析，核型分为四组：k1，正常（n = 35）；k2，仅数字改变（n = 31）；k3，简单结构异常（n = 27）；k4，复杂核型（n = 23）。患者在诊断后至少随访18个月或直至死亡。
在整个系列中（P = 0.02）以及在最大肿瘤部位亚组喉鳞状细胞癌（n = 32）中（P = 0.04），k4亚组的2年生存率（35%）低于k1、k2和k3亚组合并后的生存率（61%）。最常见的断点位于染色体带11q13，在11个肿瘤中出现，其中10个属于k4亚组。在整个系列中（P = 0.001）以及在k4亚组中（P = 0.02），有11q13重排的患者2年生存率（20%）低于无重排的患者（60%）。
结果表明，在SCCHN中，复杂核型的存在与预后不良相关，特别是当存在11q13重排时。
