Williamson T H, Baxter G M
Tennent Institute of Ophthalmology, Western Infirmary, Glasgow, Scotland.
Ophthalmology. 1994 Aug;101(8):1362-72. doi: 10.1016/s0161-6420(94)31173-0.
To determine pulsatile blood velocities in the orbital vasculature in patients with central retinal vein occlusion (CRVO).
The ophthalmic artery, central retinal artery, and vein of 80 patients with CRVO and 95 control subjects were investigated by color Doppler imaging. The patients were examined by ophthalmoscopy, relative afferent pupillary measurement using cross-polarized filters, fundus fluorescein angiography, and electroretinography to estimate the degree of retinal ischemia.
Blood flow velocities in the central retinal vein and artery of eyes with CRVO were significantly lower than in fellow eyes and controls. The measurements from the vein were most reduced and in some cases absent in those eyes with "ischemic" CRVO. Velocities also were reduced in the central retinal artery of the affected eyes, but no correlation with "ischemia" was detected. The risk of iris neovascularization in patients examined within 3 months of onset of CRVO can be determined from the flow velocities with a high degree of predictability (75% sensitivity and 86% specificity).
Blood velocity was reduced in the retinal circulation of patients with CRVO and reduced even further in the "ischemic" variant of CRVO. The results indicate that noninvasive color Doppler imaging could play a major part in the routine assessment of patients with CRVO within 3 months of onset.
测定视网膜中央静脉阻塞（CRVO）患者眼眶血管系统的搏动性血流速度。
采用彩色多普勒成像技术对80例CRVO患者及95例对照者的眼动脉、视网膜中央动脉和静脉进行研究。通过检眼镜检查、使用交叉偏振滤光片进行相对传入瞳孔测量、眼底荧光血管造影和视网膜电图检查来评估患者视网膜缺血程度。
CRVO患者患眼视网膜中央静脉和动脉的血流速度显著低于对侧眼和对照组。在“缺血性”CRVO患者中，静脉血流速度下降最为明显，某些情况下甚至无血流信号。患眼视网膜中央动脉的血流速度也降低，但未发现与“缺血”相关。在CRVO发病3个月内接受检查的患者中，可根据血流速度高度预测虹膜新生血管形成的风险（敏感性75%，特异性86%）。
CRVO患者视网膜循环血流速度降低，在“缺血性”CRVO患者中降低更为明显。结果表明，无创彩色多普勒成像在CRVO发病3个月内患者的常规评估中可发挥重要作用。
