Sherman J D
Department of Sociology, Western Michigan University, Kalamazoo, Michigan, USA.
Arch Environ Health. 1996 Jan-Feb;51(1):5-8. doi: 10.1080/00039896.1996.9935986.
Extensive and unusual patterns of birth defects noted in four children included defects of the brain, eyes, ears, palate, teeth, heart, feet, nipples, and genitalia. Brain defects were present in the ventricles, corpus callosum, choroid plexus, and septum pellucidum, and genital defects included the testes (undescended), microphallus, and labia (fused). All children had growth retardation, and three had hypotonia and profound mental retardation. The children were exposed in utero to chlorpyrifos (Dursban). Published literature and unpublished documents by the U.S. Environmental Protection Agency contain reports that identify similarities in defects found in test animals and in children exposed to Dursban. A pattern of defects found in the four children in this study may represent a heretofore unrecognized syndrome that should be considered when Dursban-exposed women have children with birth defects.
在四名儿童中发现的广泛且异常的出生缺陷模式包括大脑、眼睛、耳朵、腭、牙齿、心脏、足部、乳头和生殖器的缺陷。大脑缺陷存在于脑室、胼胝体、脉络丛和透明隔，生殖器缺陷包括睾丸（未降）、小阴茎和阴唇（融合）。所有儿童均有生长发育迟缓，三名儿童有肌张力减退和严重智力迟钝。这些儿童在子宫内接触过毒死蜱（敌百虫）。美国环境保护局的已发表文献和未发表文件包含的报告指出，在实验动物和接触敌百虫的儿童中发现的缺陷存在相似之处。本研究中四名儿童所发现的缺陷模式可能代表一种迄今为止未被认识的综合征, 当接触敌百虫的妇女产下有出生缺陷的儿童时应予以考虑。
