Cataland S, O'Dorisio T M, Brooks R, Mekhjian H S
Gastroenterology. 1977 Jul;73(1):19-22.
To investigate the role of gastric inhibitory polypeptide (GIP), a potent inhibitor of gastric acid secretion, in the hypersecretion associated with duodenal ulcer, we compared the serum GIP concentrations in 11 healthy subjects and 16 duodenal ulcer patients after the stimulation of GIP release by a mixed meal. Fasting and postprandial serum gastrin and GIP concentrations were measured by radioimmunoassay at frequent intervals after the ingestion of a test meal. The duodenal ulcer patients showed an augmented and significantly greater release of GIP as well as of gastrin compared to normal subjects. These results indicate that a defective GIP release cannot account for the gastric hypersecretion seen in patients with duodenal ulcer. The mechanism of the increased GIP response in patients with duodenal ulcer is not clear from these studies.
为了研究胃酸分泌的强效抑制剂——胃抑制性多肽（GIP）在十二指肠溃疡相关胃酸分泌过多中的作用，我们比较了11名健康受试者和16名十二指肠溃疡患者在混合餐刺激GIP释放后的血清GIP浓度。在摄入试验餐后，通过放射免疫分析法频繁测量空腹和餐后血清胃泌素和GIP浓度。与正常受试者相比，十二指肠溃疡患者的GIP以及胃泌素释放增加且显著更高。这些结果表明，GIP释放缺陷不能解释十二指肠溃疡患者出现的胃酸分泌过多。从这些研究中尚不清楚十二指肠溃疡患者GIP反应增加的机制。
